| Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility H Kallionpää, LL Elo, E Laajala, J Mykkänen, I Ricano-Ponce, M Vaarma, ... Diabetes 63 (7), 2402-2414, 2014 | 189 | 2014 |
| A practical comparison of methods for detecting transcription factor binding sites in ChIP-seq experiments TD Laajala, S Raghav, S Tuomela, R Lahesmaa, T Aittokallio, LL Elo BMC genomics 10, 1-15, 2009 | 162 | 2009 |
| Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open … J Guinney, T Wang, TD Laajala, KK Winner, JC Bare, EC Neto, SA Khan, ... The Lancet Oncology 18 (1), 132-142, 2017 | 161 | 2017 |
| Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths M Ruuth, SD Nguyen, T Vihervaara, M Hilvo, TD Laajala, PK Kondadi, ... European heart journal 39 (27), 2562-2573, 2018 | 156 | 2018 |
| PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells O Kauko, CM O’Connor, E Kulesskiy, J Sangodkar, A Aakula, S Izadmehr, ... Science translational medicine 10 (450), eaaq1093, 2018 | 141 | 2018 |
| Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy HM Haikala, JM Anttila, E Marques, T Raatikainen, M Ilander, H Hakanen, ... Nature communications 10 (1), 620, 2019 | 70 | 2019 |
| Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model M Knuuttila, E Yatkin, J Kallio, S Savolainen, TD Laajala, T Aittokallio, ... The American journal of pathology 184 (8), 2163-2173, 2014 | 64 | 2014 |
| Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling O Kauko, TD Laajala, M Jumppanen, P Hintsanen, V Suni, P Haapaniemi, ... Scientific reports 5 (1), 13099, 2015 | 61 | 2015 |
| Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 O Kauko, SY Imanishi, E Kulesskiy, L Yetukuri, TD Laajala, M Sharma, ... Journal of Biological Chemistry 295 (13), 4194-4211, 2020 | 58 | 2020 |
| The hydroxysteroid (17β) dehydrogenase family gene HSD17B12 is involved in the prostaglandin synthesis pathway, the ovarian function, and regulation of fertility H Kemiläinen, M Adam, J Mäki-Jouppila, P Damdimopoulou, ... Endocrinology 157 (10), 3719-3730, 2016 | 55 | 2016 |
| Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo TD Laajala, J Corander, NM Saarinen, K Mäkelä, S Savolainen, ... Clinical Cancer Research 18 (16), 4385-4396, 2012 | 48 | 2012 |
| Optimized design and analysis of preclinical intervention studies in vivo TD Laajala, M Jumppanen, R Huhtaniemi, V Fey, A Kaur, M Knuuttila, ... Scientific reports 6 (1), 1-13, 2016 | 45 | 2016 |
| A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions M Gabriel, V Fey, T Heinosalo, P Adhikari, K Rytkönen, T Komulainen, ... Scientific data 7 (1), 284, 2020 | 41 | 2020 |
| Novel lignan and stilbenoid mixture shows anticarcinogenic efficacy in preclinical PC-3M-luc2 prostate cancer model E Yatkin, L Polari, TD Laajala, A Smeds, C Eckerman, B Holmbom, ... PLoS One 9 (4), e93764, 2014 | 34 | 2014 |
| Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding I Björkgren, L Alvarez, N Blank, M Balbach, H Turunen, TD Laajala, ... Molecular and Cellular Endocrinology 427, 143-154, 2016 | 33 | 2016 |
| Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis T Heinosalo, M Gabriel, L Kallio, P Adhikari, K Huhtinen, TD Laajala, ... Human reproduction 33 (5), 817-831, 2018 | 28 | 2018 |
| Ovarian endometriosis signatures established through discovery and directed mass spectrometry analysis AP Vehmas, D Muth-Pawlak, K Huhtinen, T Saloniemi-Heinonen, ... Journal of proteome research 13 (11), 4983-4994, 2014 | 23 | 2014 |
| Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma J Huvila, TD Laajala, PH Edqvist, A Mardinoglu, L Talve, F Pontén, ... Gynecologic oncology 149 (1), 173-180, 2018 | 22 | 2018 |
| Adrenals contribute to growth of castration-resistant VCaP prostate cancer xenografts R Huhtaniemi, R Oksala, M Knuuttila, A Mehmood, E Aho, TD Laajala, ... The American journal of pathology 188 (12), 2890-2901, 2018 | 21 | 2018 |
| Orphan G protein-coupled receptor GPRC5A modulates integrin β1-mediated epithelial cell adhesion DR Bulanova, YA Akimov, A Rokka, TD Laajala, T Aittokallio, P Kouvonen, ... Cell adhesion & migration 11 (5-6), 434-446, 2017 | 19 | 2017 |
