Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens GM Lynn, C Sedlik, F Baharom, Y Zhu, RA Ramirez-Valdez, VL Coble, ... Nature biotechnology 38 (3), 320-332, 2020 | 249 | 2020 |
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties H Qu, D Ricklin, H Bai, H Chen, ES Reis, M Maciejewski, A Tzekou, ... Immunobiology 218 (4), 496-505, 2013 | 147 | 2013 |
Standard machine learning approaches outperform deep representation learning on phenotype prediction from transcriptomics data AM Smith, JR Walsh, J Long, CB Davis, P Henstock, MR Hodge, ... BMC bioinformatics 21, 1-18, 2020 | 69* | 2020 |
Public domain HTS fingerprints: design and evaluation of compound bioactivity profiles from PubChem’s bioassay repository KY Helal, M Maciejewski, E Gregori-Puigjane, M Glick, AM Wassermann Journal of chemical information and modeling 56 (2), 390-398, 2016 | 61 | 2016 |
Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets M Maciejewski, E Lounkine, S Whitebread, P Farmer, W DuMouchel, ... Elife 6, e25818, 2017 | 50 | 2017 |
Profiling of gene expression biomarkers as a classifier of methotrexate nonresponse in patients with rheumatoid arthritis D Plant, M Maciejewski, S Smith, N Nair, ... Arthritis & Rheumatology 71 (5), 678-684, 2019 | 48 | 2019 |
Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor HJ Park, M Guariento, M Maciejewski, R Hauhart, WH Tham, AF Cowman, ... Journal of Biological Chemistry 289 (1), 450-463, 2014 | 41 | 2014 |
Solution structure of CCP modules 10–12 illuminates functional architecture of the complement regulator, factor H E Makou, HDT Mertens, M Maciejewski, DC Soares, I Matis, CQ Schmidt, ... Journal of molecular biology 424 (5), 295-312, 2012 | 33 | 2012 |
A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease L Han, M Maciejewski, C Brockel, W Gordon, SB Snapper, JR Korzenik, ... Bioinformatics 34 (6), 985-993, 2018 | 30 | 2018 |
Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings M Maciejewski, N Tjandra, PN Barlow Biochemistry 50 (38), 8138-8149, 2011 | 28 | 2011 |
Implications of dynamic occupancy, binding kinetics, and channel gating kinetics for hERG blocker safety assessment and mitigation R A Pearlstein, K Andrew MacCannell, G Erdemli, S Yeola, G Helmlinger, ... Current Topics in Medicinal Chemistry 16 (16), 1792-1818, 2016 | 26 | 2016 |
Early prediction of clinical response to anti-TNF treatment using multi-omics and machine learning in rheumatoid arthritis N Yoosuf, M Maciejewski, D Ziemek, SA Jelinsky, L Folkersen, M Müller, ... Rheumatology 61 (4), 1680-1689, 2022 | 25 | 2022 |
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics M Maciejewski, C Sands, N Nair, S Ling, S Verstappen, K Hyrich, A Barton, ... Scientific Reports 11 (1), 7266, 2021 | 25 | 2021 |
The RA-MAP Consortium: a working model for academia–industry collaboration AP Cope, MR Barnes, A Belson, M Binks, S Brockbank, ... Nature Reviews Rheumatology 14 (1), 53-60, 2018 | 22 | 2018 |
Diversity Selection of Compounds Based on ‘Protein Affinity Fingerprints’ Improves Sampling of Bioactive Chemical Space HP Nguyen, A Koutsoukas, F Mohd Fauzi, G Drakakis, M Maciejewski, ... Chemical Biology & Drug Design 82 (3), 252-266, 2013 | 22 | 2013 |
Molecular profiling of ulcerative colitis subjects from the TURANDOT trial reveals novel pharmacodynamic/efficacy biomarkers H Zhou, L Xi, D Ziemek, S O’Neil, J Lee, Z Stewart, Y Zhan, S Zhao, ... Journal of Crohn's and Colitis 13 (6), 702-713, 2019 | 19 | 2019 |
Experimental Design Strategy: Weak Reinforcement Leads to Increased Hit Rates and Enhanced Chemical Diversity M Maciejewski, AM Wassermann, M Glick, E Lounkine Journal of chemical information and modeling, 2015 | 17 | 2015 |
What is the persistence to methotrexate in rheumatoid arthritis, and does machine learning outperform hypothesis‐based approaches to its prediction? H Westerlind, M Maciejewski, T Frisell, SA Jelinsky, D Ziemek, J Askling ACR Open Rheumatology 3 (7), 457-463, 2021 | 15 | 2021 |
Translation of off-target effects: prediction of ADRs by integrated experimental and computational approach L Urban, M Maciejewski, E Lounkine, S Whitebread, JL Jenkins, J Hamon, ... Toxicology Research 3 (6), 433-444, 2014 | 15 | 2014 |
Maximising therapeutic utility in rheumatoid arthritis consortium tRSG D Plant, M Maciejewski, S Smith, N Nair, K Hyrich, D Ziemek, A Barton, ... Profiling of gene expression biomarkers as a classifier of methotrexate …, 2019 | 11 | 2019 |