Motomu Shimaoka
Motomu Shimaoka
Mie University Graduate School of Medicine
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Conformational regulation of integrin structure and function
M Shimaoka, J Takagi, TA Springer
Annual review of biophysics and biomolecular structure 31 (1), 485-516, 2002
Structures of the αL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
M Shimaoka, T Xiao, JH Liu, Y Yang, Y Dong, CD Jun, A McCormack, ...
Cell 112 (1), 99-111, 2003
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
D Peer, EJ Park, Y Morishita, CV Carman, M Shimaoka
Science 319 (5863), 627-630, 2008
Therapeutic antagonists and conformational regulation of integrin function
M Shimaoka, TA Springer
Nature Reviews Drug Discovery 2 (9), 703-716, 2003
Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1
D Peer, P Zhu, CV Carman, J Lieberman, M Shimaoka
Proceedings of the National Academy of Sciences 104 (10), 4095-4100, 2007
Activation of leukocyte β2 integrins by conversion from bent to extended conformations
N Nishida, C Xie, M Shimaoka, Y Cheng, T Walz, TA Springer
Immunity 25 (4), 583-594, 2006
Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin αL I domains with high affinity and antagonist activity in vivo
M Shimaoka, C Lu, RT Palframan, UH von Andrian, A McCormack, ...
Proceedings of the National Academy of Sciences 98 (11), 6009-6014, 2001
Identification of the target self-antigens in reperfusion injury
M Zhang, EM Alicot, I Chiu, J Li, N Verna, T Vorup-Jensen, B Kessler, ...
The Journal of experimental medicine 203 (1), 141-152, 2006
Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-β1 mRNA upregulation in rat lungs
H Imanaka, M Shimaoka, N Matsuura, M Nishimura, N Ohta, H Kiyono
Anesthesia & Analgesia 92 (2), 428-436, 2001
Rolling adhesion through an extended conformation of integrin αLβ2 and relation to α I and β I-like domain interaction
A Salas, M Shimaoka, AN Kogan, C Harwood, UH von Andrian, ...
Immunity 20 (4), 393-406, 2004
Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains
C Lu, M Shimaoka, Q Zang, J Takagi, TA Springer
Proceedings of the National Academy of Sciences 98 (5), 2393-2398, 2001
RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice
SS Kim, D Peer, P Kumar, S Subramanya, H Wu, D Asthana, K Habiro, ...
Molecular therapy 18 (2), 370-376, 2010
Computational design of an integrin I domain stabilized in the open high affinity conformation
M Shimaoka, JM Shifman, H Jing, J Takagi, SL Mayo, TA Springer
Nature structural biology 7 (8), 674-678, 2000
Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism
S Podgrabinska, O Kamalu, L Mayer, M Shimaoka, H Snoeck, ...
The Journal of Immunology 183 (3), 1767-1779, 2009
An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond
C Lu, M Shimaoka, M Ferzly, C Oxvig, J Takagi, TA Springer
Proceedings of the National Academy of Sciences 98 (5), 2387-2392, 2001
Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration
NA Morin, PW Oakes, YM Hyun, D Lee, YE Chin, MR King, TA Springer, ...
The Journal of experimental medicine 205 (1), 195-205, 2008
Small molecule integrin antagonists that bind to the β2 subunit I-like domain and activate signals in one direction and block them in the other
M Shimaoka, A Salas, W Yang, G Weitz-Schmidt, TA Springer
Immunity 19 (3), 391-402, 2003
Importance of force linkage in mechanochemistry of adhesion receptors
NS Astrof, A Salas, M Shimaoka, JF Chen, TA Springer
Biochemistry 45 (50), 15020-15028, 2006
Set positive end-expiratory pressure during protective ventilation affects lung injury
M Takeuchi, S Goddon, M Dolhnikoff, M Shimaoka, D Hess, MBP Amato, ...
The Journal of the American Society of Anesthesiologists 97 (3), 682-692, 2002
Advances in understanding sepsis
M Shimaoka, EJ Park
European Journal of Anaesthesiology 25 (S42), 146-153, 2008
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