| Conformational regulation of integrin structure and function M Shimaoka, J Takagi, TA Springer Annual review of biophysics and biomolecular structure 31 (1), 485-516, 2002 | 712 | 2002 |
| Structures of the αL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation M Shimaoka, T Xiao, JH Liu, Y Yang, Y Dong, CD Jun, A McCormack, ... Cell 112 (1), 99-111, 2003 | 637 | 2003 |
| Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target D Peer, EJ Park, Y Morishita, CV Carman, M Shimaoka Science 319 (5863), 627-630, 2008 | 580 | 2008 |
| Therapeutic antagonists and conformational regulation of integrin function M Shimaoka, TA Springer Nature Reviews Drug Discovery 2 (9), 703-716, 2003 | 471 | 2003 |
| Activation of leukocyte β2 integrins by conversion from bent to extended conformations N Nishida, C Xie, M Shimaoka, Y Cheng, T Walz, TA Springer Immunity 25 (4), 583-594, 2006 | 337 | 2006 |
| Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1 D Peer, P Zhu, CV Carman, J Lieberman, M Shimaoka Proceedings of the National Academy of Sciences 104 (10), 4095-4100, 2007 | 334 | 2007 |
| Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo M Shimaoka, C Lu, RT Palframan, UH von Andrian, A McCormack, ... Proceedings of the National Academy of Sciences 98 (11), 6009-6014, 2001 | 300 | 2001 |
| Identification of the target self-antigens in reperfusion injury M Zhang, EM Alicot, I Chiu, J Li, N Verna, T Vorup-Jensen, B Kessler, ... The Journal of experimental medicine 203 (1), 141-152, 2006 | 273 | 2006 |
| Rolling adhesion through an extended conformation of integrin αLβ2 and relation to α I and β I-like domain interaction A Salas, M Shimaoka, AN Kogan, C Harwood, UH von Andrian, ... Immunity 20 (4), 393-406, 2004 | 262 | 2004 |
| Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-β1 mRNA upregulation in rat lungs H Imanaka, M Shimaoka, N Matsuura, M Nishimura, N Ohta, H Kiyono Anesthesia & Analgesia 92 (2), 428-436, 2001 | 262 | 2001 |
| RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice SS Kim, D Peer, P Kumar, S Subramanya, H Wu, D Asthana, K Habiro, ... Molecular therapy 18 (2), 370-376, 2010 | 248 | 2010 |
| Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains C Lu, M Shimaoka, Q Zang, J Takagi, TA Springer Proceedings of the National Academy of Sciences 98 (5), 2393-2398, 2001 | 227 | 2001 |
| Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism S Podgrabinska, O Kamalu, L Mayer, M Shimaoka, H Snoeck, ... The Journal of Immunology 183 (3), 1767-1779, 2009 | 218 | 2009 |
| Computational design of an integrin I domain stabilized in the open high affinity conformation M Shimaoka, JM Shifman, H Jing, J Takagi, SL Mayo, TA Springer Nature structural biology 7 (8), 674-678, 2000 | 178 | 2000 |
| An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond C Lu, M Shimaoka, M Ferzly, C Oxvig, J Takagi, TA Springer Proceedings of the National Academy of Sciences 98 (5), 2387-2392, 2001 | 167 | 2001 |
| Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration NA Morin, PW Oakes, YM Hyun, D Lee, YE Chin, MR King, TA Springer, ... The Journal of experimental medicine 205 (1), 195-205, 2008 | 165 | 2008 |
| Importance of force linkage in mechanochemistry of adhesion receptors NS Astrof, A Salas, M Shimaoka, JF Chen, TA Springer Biochemistry 45 (50), 15020-15028, 2006 | 157 | 2006 |
| Small molecule integrin antagonists that bind to the β2 subunit I-like domain and activate signals in one direction and block them in the other M Shimaoka, A Salas, W Yang, G Weitz-Schmidt, TA Springer Immunity 19 (3), 391-402, 2003 | 156 | 2003 |
| Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling J Zhu, CV Carman, M Kim, M Shimaoka, TA Springer, BH Luo Blood, The Journal of the American Society of Hematology 110 (7), 2475-2483, 2007 | 150 | 2007 |
| Advances in understanding sepsis M Shimaoka, EJ Park European Journal of Anaesthesiology 25 (S42), 146-153, 2008 | 148 | 2008 |
