Presence of Nonhemolytic Pneumolysin in Serotypes of Streptococcus pneumoniae Associated with Disease Outbreaks JMC Jefferies, CHG Johnston, LAS Kirkham, GJM Cowan, KS Ross, ... Journal of Infectious Diseases 196 (6), 936-944, 2007 | 113 | 2007 |
α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized … L Stevenson, E Laursen, GJ Cowan, B Bandoh, L Barfod, DR Cavanagh, ... PLoS pathogens 11 (7), e1005022, 2015 | 90 | 2015 |
The human‐specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein H Nagamune, K Ohkura, A Sukeno, G Cowan, TJ Mitchell, W Ito, ... Microbiology and immunology 48 (9), 677-692, 2004 | 58 | 2004 |
The mechanism of pneumolysin‐induced cochlear hair cell death in the rat M Beurg, A Hafidi, L Skinner, G Cowan, Y Hondarrague, TJ Mitchell, ... The Journal of physiology 568 (1), 211-227, 2005 | 49 | 2005 |
Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria N Imai, N Rujeni, N Nausch, CD Bourke, LJ Appleby, G Cowan, R Gwisai, ... Parasitology 138 (12), 1519-1533, 2011 | 47 | 2011 |
Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae G Douce, K Ross, G Cowan, J Ma, TJ Mitchell Vaccine 28 (18), 3231-3237, 2010 | 43 | 2010 |
Pneumolysin‐mediated activation of NFκB in human neutrophils is antagonized by docosahexaenoic acid H Fickl, R Cockeran, HC Steel, C Feldman, G Cowan, TJ Mitchell, ... Clinical & Experimental Immunology 140 (2), 274-281, 2005 | 42 | 2005 |
A malaria vaccine based on the polymorphic block 2 region of MSP-1 that elicits a broad serotype-spanning immune response GJM Cowan, AM Creasey, K Dhanasarnsombut, AW Thomas, ... PLoS One 6 (10), e26616, 2011 | 36 | 2011 |
immune Tolerance to apoptotic self is Mediated Primarily by regulatory B1a cells K Miles, J Simpson, S Brown, G Cowan, D Gray, M Gray Frontiers in immunology 8, 1952, 2018 | 34 | 2018 |
Loss of the protein tyrosine phosphatase PTPN22 reduces mannan-induced autoimmune arthritis in SKG mice S Sood, RJ Brownlie, C Garcia, G Cowan, RJ Salmond, S Sakaguchi, ... The Journal of Immunology 197 (2), 429-440, 2016 | 26 | 2016 |
Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59 TR Hughes, KS Ross, GJM Cowan, B Sivasankar, CL Harris, TJ Mitchell, ... Molecular immunology 46 (7), 1561-1567, 2009 | 26 | 2009 |
Immunisation with anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis GJM Cowan, HS Atkins, LK Johnson, RW Titball, TJ Mitchell Vaccine 25 (41), 7197-7205, 2007 | 25 | 2007 |
A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila GJM Cowan, U Bockau, J Eleni-Muus, I Aldag, K Samuel, AM Creasey, ... PloS one 9 (1), e87198, 2014 | 24 | 2014 |
In human autoimmunity, a substantial component of the B cell repertoire consists of polyclonal, barely mutated IgG+ ve B cells GJM Cowan, K Miles, L Capitani, SSB Giguere, H Johnsson, ... Frontiers in Immunology 11, 395, 2020 | 22 | 2020 |
Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma G Cowan, NJ Weston-Bell, D Bryant, A Seckinger, D Hose, N Zojer, ... Oncotarget 6 (15), 13229, 2015 | 22 | 2015 |
Abnormal proliferation and spontaneous differentiation of myoblasts from a symptomatic female carrier of X-linked Emery–Dreifuss muscular dystrophy P Meinke, P Schneiderat, V Srsen, N Korfali, P Lê Thành, GJM Cowan, ... Neuromuscular Disorders 25 (2), 127-136, 2015 | 22 | 2015 |
Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys DR Cavanagh, CHM Kocken, JH White, GJM Cowan, K Samuel, ... PLoS One 9 (1), e83704, 2014 | 19 | 2014 |
Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni M Higon, G Cowan, N Nausch, D Cavanagh, A Oleaga, R Toledo, ... Parasitology 138 (12), 1607-1619, 2011 | 17 | 2011 |
Immunological consequences of antihelminthic treatment in preschool children exposed to urogenital schistosome infection N Rujeni, N Nausch, N Midzi, GJ Cowan, R Burchmore, DR Cavanagh, ... Journal of tropical medicine 2013, 2013 | 13 | 2013 |
A Conserved TCRβ signature dominates a highly polyclonal T-cell expansion during the acute phase of a murine malaria infection NL Smith, W Nahrendorf, C Sutherland, JP Mooney, J Thompson, ... Frontiers in immunology 11, 587756, 2020 | 11 | 2020 |