| Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus K Shin-ya, K Wierzba, K Matsuo, T Ohtani, Y Yamada, K Furihata, ... Journal of the American Chemical Society 123 (6), 1262-1263, 2001 | 694 | 2001 |
| Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex MY Kim, H Vankayalapati, K Shin-Ya, K Wierzba, LH Hurley Journal of the American Chemical Society 124 (10), 2098-2099, 2002 | 692 | 2002 |
| Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer T Utsugi, J Shibata, Y Sugimoto, K Aoyagi, K Wierzba, T Kobunai, ... Cancer research 56 (12), 2809-2814, 1996 | 177 | 1996 |
| Antitumor activity of a novel quinoline derivative, TAS‐103, with inhibitory effects on topoisomerases I and II T Utsugi, K Aoyagi, T Asao, S Okazaki, Y Aoyagi, M Sano, K Wierzba, ... Japanese journal of cancer research 88 (10), 992-1002, 1997 | 149 | 1997 |
| UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice K Yonekura, Y Basaki, L Chikahisa, S Okabe, A Hashimoto, K Miyadera, ... Clinical cancer research 5 (8), 2185-2191, 1999 | 137 | 1999 |
| Mechanism of action of a new macromolecular antitumor antibiotic, C-1027 Y Sugimoto, T Otani, S OIE, K Wierzba, Y Yamada The Journal of antibiotics 43 (4), 417-421, 1990 | 106 | 1990 |
| γ-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor Y Basaki, L Chikahisa, K Aoyagi, K Miyadera, K Yonekura, A Hashimoto, ... Angiogenesis 4, 163-173, 2001 | 85 | 2001 |
| Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine … S Yano, H Kazuno, T Sato, N Suzuki, T Emura, K Wierzba, J Yamashita, ... Bioorganic & medicinal chemistry 12 (13), 3443-3450, 2004 | 74 | 2004 |
| Antitumor agents. 3. Synthesis and biological activity of 4. beta.-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as … T Terada, K Fujimoto, M Nomura, J Yamashita, K Wierzba, R Yamazaki, ... Journal of medicinal chemistry 36 (12), 1689-1699, 1993 | 73 | 1993 |
| Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display library S Ohkubo, K Miyadera, Y Sugimoto, K Matsuo, K Wierzba, Y Yamada Biochemical and Biophysical Research Communications 266 (2), 308-313, 1999 | 59 | 1999 |
| TAT-59, a new triphenylethylene derivative with antitumor activity against hormone-dependent tumors T Toko, Y Sugimoto, KI Matsuo, R Yamasaki, S Takeda, K Wierzba, ... European Journal of Cancer and Clinical Oncology 26 (3), 397-404, 1990 | 54 | 1990 |
| Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: discovery of novel orally active inhibitors of human thymidine phosphorylase S Yano, H Kazuno, N Suzuki, T Emura, K Wierzba, J Yamashita, Y Tada, ... Bioorganic & medicinal chemistry 12 (13), 3431-3441, 2004 | 51 | 2004 |
| TAS-108, a novel oral steroidal antiestrogenic agent, is a pure antagonist on estrogen receptor α and a partial agonist on estrogen receptor β with low uterotrophic effect Y Yamamoto, J Shibata, K Yonekura, K Sato, A Hashimoto, Y Aoyagi, ... Clinical cancer research 11 (1), 315-322, 2005 | 46 | 2005 |
| Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents T TERADA, K FUJIMOTO, M NOMURA, J YAMASHITA, T KOBUNAI, ... Chemical and Pharmaceutical Bulletin 40 (10), 2720-2727, 1992 | 46 | 1992 |
| Synthesis and reactivity of 5, 8-dihydroxythioflavanone derivatives MT Konieczny, B Horowska, A Kunikowski, J Konopa, K Wierzba, ... The Journal of Organic Chemistry 64 (2), 359-364, 1999 | 39 | 1999 |
| Tubulin as a major determinant of tissue distribution of vincristine K Wierzba, Y Sugiyama, K Okudaira, T Iga, M Hanano Journal of pharmaceutical sciences 76 (12), 872-875, 1987 | 35 | 1987 |
| Substrate phage as a tool to identify novel substrate sequences of proteases S Ohkubo, K Miyadera, Y Sugimoto, K Matsuo, K Wierzba, Y Yamada Combinatorial Chemistry & High Throughput Screening 4 (7), 573-583, 2001 | 34 | 2001 |
| Napthalimidobenzamide DB-51630: a novel DNA binding agent inducing p300 gene expression and exerting a potent anti-cancer activity K Suzuki, H Nagasawa, Y Uto, Y Sugimoto, K Noguchi, M Wakida, ... Bioorganic & medicinal chemistry 13 (12), 4014-4021, 2005 | 33 | 2005 |
| TAC-101, a benzoic acid derivative, inhibits liver metastasis of human gastrointestinal cancer and prolongs the life-span K Murakami, K Wierzba, M Sano, J Shibata, K Yonekura, A Hashimoto, ... Clinical & experimental metastasis 16, 323-331, 1998 | 31 | 1998 |
| Estimation of skin concentrations of topically applied lidocaine at each depth profile T Oshizaka, K Kikuchi, WR Kadhum, H Todo, T Hatanaka, K Wierzba, ... International journal of pharmaceutics 475 (1-2), 292-297, 2014 | 29 | 2014 |
