Tong Li
Tong Li
Assistant Professor of pathology, the Johns Hopkins University
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Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes
KS Vetrivel, H Cheng, W Lin, T Sakurai, T Li, N Nukina, PC Wong, H Xu, ...
Journal of Biological Chemistry 279 (43), 44945-44954, 2004
Nicastrin is required for assembly of presenilin/γ-secretase complexes to mediate Notch signaling and for processing and trafficking of β-amyloid precursor protein in mammals
T Li, G Ma, H Cai, DL Price, PC Wong
Journal of Neuroscience 23 (8), 3272-3277, 2003
Accelerated Aβ deposition in APPswe/PS1ΔE9 mice with hemizygous deletions of TTR (transthyretin)
SH Choi, SN Leight, VMY Lee, T Li, PC Wong, JA Johnson, MJ Saraiva, ...
Journal of Neuroscience 27 (26), 7006-7010, 2007
CP1 domain in Escherichia coli leucyl-tRNA synthetase is crucial for its editing function
JF Chen, NN Guo, T Li, ED Wang, YL Wang
Biochemistry 39 (22), 6726-6731, 2000
Glu332 in the nicastrin ectodomain is essential for γ-secretase complex maturation but not for its activity
L Chávez-Gutiérrez, A Tolia, E Maes, T Li, PC Wong, B De Strooper
Journal of Biological Chemistry 283 (29), 20096-20105, 2008
APH-1a is the principal mammalian APH-1 isoform present in γ-secretase complexes during embryonic development
G Ma, T Li, DL Price, PC Wong
Journal of Neuroscience 25 (1), 192-198, 2005
One polypeptide with two aminoacyl-tRNA synthetase activities
C Stathopoulos, T Li, R Longman, UC Vothknecht, HD Becker, M Ibba, ...
Science 287 (5452), 479-482, 2000
Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of γ-secretase
T Li, H Wen, C Brayton, P Das, LA Smithson, A Fauq, X Fan, BJ Crain, ...
Journal of Biological Chemistry 282 (44), 32264-32273, 2007
Moderate reduction of γ-secretase attenuates amyloid burden and limits mechanism-based liabilities
T Li, H Wen, C Brayton, FM Laird, G Ma, S Peng, L Placanica, TC Wu, ...
Journal of Neuroscience 27 (40), 10849-10859, 2007
Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin
I Hayashi, S Takatori, Y Urano, Y Miyake, J Takagi, M Sakata-Yanagimoto, ...
Oncogene 31 (6), 787-798, 2012
Archaeal aminoacyl-tRNA synthesis: diversity replaces dogma
D Tumbula, UC Vothknecht, H Kim, M Ibba, B Min, T Li, J Pelaschier, ...
Genetics 152 (4), 1269-1276, 1999
Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties
V Mahairaki, J Ryu, A Peters, Q Chang, T Li, TS Park, PW Burridge, ...
Stem cells and development 23 (24), 2996-3010, 2014
S-palmitoylation of γ-secretase subunits nicastrin and APH-1
H Cheng, KS Vetrivel, RC Drisdel, X Meckler, P Gong, JY Leem, T Li, ...
Journal of Biological Chemistry 284 (3), 1373-1384, 2009
Papillomavirus infection requires γ secretase
B Karanam, S Peng, T Li, C Buck, PM Day, RBS Roden
Journal of virology 84 (20), 10661-10670, 2010
Cysteinyl-tRNA synthetase is not essential for viability of the archaeon Methanococcus maripaludis
C Stathopoulos, W Kim, T Li, I Anderson, B Deutsch, S Palioura, ...
Proceedings of the National Academy of Sciences 98 (25), 14292-14297, 2001
Alzheimer's therapeutics: translation of preclinical science to clinical drug development
AV Savonenko, T Melnikova, A Hiatt, T Li, PF Worley, JC Troncoso, ...
Neuropsychopharmacology 37 (1), 261-277, 2012
Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients
A Hatzimanolis, JA McGrath, R Wang, T Li, PC Wong, G Nestadt, ...
Translational psychiatry 3 (5), e264-e264, 2013
Modeling an anti-amyloid combination therapy for Alzheimer’s disease
VW Chow, AV Savonenko, T Melnikova, H Kim, DL Price, T Li, PC Wong
Science translational medicine 2 (13), 13ra1-13ra1, 2010
The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model
T Li, KE Braunstein, J Zhang, A Lau, L Sibener, C Deeble, PC Wong
Nature communications 7 (1), 1-13, 2016
Binding sites of γ-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation
XX Yan, T Li, CM Rominger, SR Prakash, PC Wong, RE Olson, R Zaczek, ...
Journal of Neuroscience 24 (12), 2942-2952, 2004
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