Makoto Urushitani
Makoto Urushitani
Shiga University of Medical Science
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Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
M Urushitani, A Sik, T Sakurai, N Nukina, R Takahashi, JP Julien
Nature neuroscience 9 (1), 108-118, 2006
Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis
M Urushitani, J Kurisu, K Tsukita, R Takahashi
Journal of neurochemistry 83 (5), 1030-1042, 2002
Estradiol protects mesencephalic dopaminergic neurons from oxidative stress‐induced neuronal death
H Sawada, M Ibi, T Kihara, M Urushitani, A Akaike, S Shimohama
Journal of neuroscience research 54 (5), 707-719, 1998
Phosphatidylinositol 3‐kinase mediates neuroprotection by estrogen in cultured cortical neurons
K Honda, H Sawada, T Kihara, M Urushitani, T Nakamizo, A Akaike, ...
Journal of neuroscience research 60 (3), 321-327, 2000
Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury
W Zhao, DR Beers, JS Henkel, W Zhang, M Urushitani, JP Julien, ...
Glia 58 (2), 231-243, 2010
Wild‐type superoxide dismutase acquires binding and toxic properties of ALS‐linked mutant forms through oxidation
SA Ezzi, M Urushitani, JP Julien
Journal of neurochemistry 102 (1), 170-178, 2007
Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
M Urushitani, SA Ezzi, JP Julien
Proceedings of the National Academy of Sciences 104 (7), 2495-2500, 2007
Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity
T Kihara, S Shimohama, M Urushitani, H Sawada, J Kimura, T Kume, ...
Brain research 792 (2), 331-334, 1998
In vivo evidence of CHIP up‐regulation attenuating tau aggregation
N Sahara, M Murayama, T Mizoroki, M Urushitani, Y Imai, R Takahashi, ...
Journal of neurochemistry 94 (5), 1254-1263, 2005
Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons
H Sawada, M Ibi, T Kihara, M Urushitani, K Honda, M Nakanishi, A Akaike, ...
The FASEB Journal 14 (9), 1202-1214, 2000
CHIP promotes proteasomal degradation of familial ALS‐linked mutant SOD1 by ubiquitinating Hsp/Hsc70
M Urushitani, J Kurisu, M Tateno, S Hatakeyama, KI Nakayama, S Kato, ...
Journal of neurochemistry 90 (1), 231-244, 2004
N‐methyl‐D‐aspartate receptor‐mediated mitochondrial Ca2+ overload in acute excitotoxic motor neuron death: A mechanism distinct from chronic neurotoxicity after Ca …
M Urushitani, R Inoue, H Sawada, T Kihara, K Honda, A Akaike, ...
Journal of neuroscience research 63 (5), 377-387, 2001
Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis
Y Tashiro, M Urushitani, H Inoue, M Koike, Y Uchiyama, M Komatsu, ...
Journal of Biological Chemistry 287 (51), 42984-42994, 2012
Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model
M Tateno, H Sadakata, M Tanaka, S Itohara, RM Shin, M Miura, ...
Human molecular genetics 13 (19), 2183-2196, 2004
Relationship between the tautomeric structures of curcumin derivatives and their Aβ-binding activities in the context of therapies for Alzheimer's disease
D Yanagisawa, N Shirai, T Amatsubo, H Taguchi, K Hirao, M Urushitani, ...
Biomaterials 31 (14), 4179-4185, 2010
Dopamine D2‐type agonists protect mesencephalic neurons from glutamate neurotoxicity: Mechanisms of neuroprotective treatment against oxidative stress
H Sawada, M Ibi, T Kihara, M Urushitani, A Akaike, J Kimura, ...
Annals of Neurology: Official Journal of the American Neurological …, 1998
Neuroprotective mechanism of glial cell line‐derived neurotrophic factor in mesencephalic neurons
H Sawada, M Ibi, T Kihara, M Urushitani, M Nakanishi, A Akaike, ...
Journal of neurochemistry 74 (3), 1175-1184, 2000
Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP‐43
M Urushitani, T Sato, H Bamba, Y Hisa, I Tooyama
Journal of neuroscience research 88 (4), 784-797, 2010
Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate‐induced nitric oxide in motor neuron toxicity and nonmotor …
M Urushitani, S Shimohama, T Kihara, H Sawada, A Akaike, M Ibi, ...
Annals of neurology 44 (5), 796-807, 1998
The endoplasmic reticulum‐Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS
M Urushitani, SA Ezzi, A Matsuo, I Tooyama, JP Julien
The FASEB Journal 22 (7), 2476-2487, 2008
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