| A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth S Bonnet, SL Archer, J Allalunis-Turner, A Haromy, C Beaulieu, ... Cancer cell 11 (1), 37-51, 2007 | 1978 | 2007 |
| Metabolic modulation of glioblastoma with dichloroacetate ED Michelakis, G Sutendra, P Dromparis, L Webster, A Haromy, E Niven, ... Science translational medicine 2 (31), 31ra34-31ra34, 2010 | 913 | 2010 |
| Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer ED Michelakis, L Webster, JR Mackey British journal of cancer 99 (7), 989-994, 2008 | 879 | 2008 |
| Inflammation, growth factors, and pulmonary vascular remodeling PM Hassoun, L Mouthon, JA Barberà, S Eddahibi, SC Flores, ... Journal of the american college of cardiology 54 (1_Supplement_S), S10-S19, 2009 | 867 | 2009 |
| Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide E Michelakis, W Tymchak, D Lien, L Webster, K Hashimoto, S Archer Circulation 105 (20), 2398-2403, 2002 | 783 | 2002 |
| An abnormal mitochondrial–hypoxia inducible factor-1α–Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities … S Bonnet, ED Michelakis, CJ Porter, MA Andrade-Navarro, B Thébaud, ... Circulation 113 (22), 2630-2641, 2006 | 682 | 2006 |
| Relevant issues in the pathology and pathobiology of pulmonary hypertension RM Tuder, SL Archer, P Dorfmüller, SC Erzurum, C Guignabert, ... Journal of the American College of Cardiology 62 (25S), D4-D12, 2013 | 675 | 2013 |
| Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility J Nagendran, SL Archer, D Soliman, V Gurtu, R Moudgil, A Haromy, ... Circulation 116 (3), 238-248, 2007 | 625 | 2007 |
| Hypoxic pulmonary vasoconstriction R Moudgil, ED Michelakis, SL Archer Journal of applied physiology 98 (1), 390-403, 2005 | 614 | 2005 |
| A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation G Sutendra, A Kinnaird, P Dromparis, R Paulin, TH Stenson, A Haromy, ... Cell 158 (1), 84-97, 2014 | 585 | 2014 |
| Comprehensive invasive and noninvasive approach to the right ventricle–pulmonary circulation unit: state of the art and clinical and research implications HC Champion, ED Michelakis, PM Hassoun Circulation 120 (11), 992-1007, 2009 | 579 | 2009 |
| Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that … B Thébaud, F Ladha, ED Michelakis, M Sawicka, G Thurston, F Eaton, ... Circulation 112 (16), 2477-2486, 2005 | 574 | 2005 |
| Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis MS McMurtry, S Bonnet, X Wu, JRB Dyck, A Haromy, K Hashimoto, ... Circulation research 95 (8), 830-840, 2004 | 574 | 2004 |
| Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension ED Michelakis, W Tymchak, M Noga, L Webster, XC Wu, D Lien, ... Circulation 108 (17), 2066-2069, 2003 | 530 | 2003 |
| Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension MS McMurtry, SL Archer, DC Altieri, S Bonnet, A Haromy, G Harry, ... The Journal of clinical investigation 115 (6), 1479-1491, 2005 | 483 | 2005 |
| Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated … ED Michelakis, MS McMurtry, XC Wu, JRB Dyck, R Moudgil, TA Hopkins, ... Circulation 105 (2), 244-250, 2002 | 469 | 2002 |
| The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted S Bonnet, G Rochefort, G Sutendra, SL Archer, A Haromy, L Webster, ... Proceedings of the National Academy of Sciences 104 (27), 11418-11423, 2007 | 453 | 2007 |
| Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia SL Archer, JMC Huang, HL Reeve, V Hampl, S Tolarová, E Michelakis, ... Circulation research 78 (3), 431-442, 1996 | 426 | 1996 |
| Metabolic control of epigenetics in cancer A Kinnaird, S Zhao, KE Wellen, ED Michelakis Nature Reviews Cancer 16 (11), 694-707, 2016 | 416 | 2016 |
| Diversity in mitochondrial function explains differences in vascular oxygen sensing ED Michelakis, V Hampl, A Nsair, XC Wu, G Harry, A Haromy, R Gurtu, ... Circulation research 90 (12), 1307-1315, 2002 | 388 | 2002 |
