The effect of HPMCAS functional groups on drug crystallization from the supersaturated state and dissolution improvement K Ueda, K Higashi, K Yamamoto, K Moribe International journal of pharmaceutics 464 (1-2), 205-213, 2014 | 125 | 2014 |
Inhibitory effect of hydroxypropyl methylcellulose acetate succinate on drug recrystallization from a supersaturated solution assessed using nuclear magnetic resonance measurements K Ueda, K Higashi, K Yamamoto, K Moribe Molecular pharmaceutics 10 (10), 3801-3811, 2013 | 116 | 2013 |
Recent progress of structural study of polymorphic pharmaceutical drugs K Higashi, K Ueda, K Moribe Advanced drug delivery reviews 117, 71-85, 2017 | 90 | 2017 |
Self‐Degradable Lipid‐Like Materials Based on “Hydrolysis accelerated by the intra‐Particle Enrichment of Reactant (HyPER)” for Messenger RNA Delivery H Tanaka, T Takahashi, M Konishi, N Takata, M Gomi, D Shirane, ... Advanced Functional Materials 30 (34), 1910575, 2020 | 78 | 2020 |
Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements K Ueda, K Higashi, W Limwikrant, S Sekine, T Horie, K Yamamoto, ... Molecular pharmaceutics 9 (11), 3023-3033, 2012 | 73 | 2012 |
Synergetic role of hypromellose and methacrylic acid copolymer in the dissolution improvement of amorphous solid dispersions N Ohyagi, K Ueda, K Higashi, K Yamamoto, K Kawakami, K Moribe Journal of pharmaceutical sciences 106 (4), 1042-1050, 2017 | 53 | 2017 |
Nano-scale and molecular-level understanding of wet-milled indomethacin/poloxamer 407 nanosuspension with TEM, suspended-state NMR, and Raman measurements Y Kuroiwa, K Higashi, K Ueda, K Yamamoto, K Moribe International journal of pharmaceutics 537 (1-2), 30-39, 2018 | 43 | 2018 |
An insight into different stabilization mechanisms of phenytoin derivatives supersaturation by HPMC and PVP N Otsuka, K Ueda, N Ohyagi, K Shimizu, K Katakawa, T Kumamoto, ... Journal of pharmaceutical sciences 104 (8), 2574-2582, 2015 | 42 | 2015 |
Polymer type impacts amorphous solubility and drug-rich phase colloidal stability: A mechanistic study using nuclear magnetic resonance spectroscopy K Ueda, LS Taylor Molecular Pharmaceutics 17 (4), 1352-1362, 2020 | 41 | 2020 |
DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy M Kawai, T Nakamura, N Miura, M Maeta, H Tanaka, K Ueda, K Higashi, ... Nanomedicine: Nanotechnology, Biology and Medicine 14 (8), 2587-2597, 2018 | 41 | 2018 |
Direct NMR monitoring of phase separation behavior of highly supersaturated nifedipine solution stabilized with hypromellose derivatives K Ueda, K Higashi, K Moribe Molecular pharmaceutics 14 (7), 2314-2322, 2017 | 41 | 2017 |
Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution K Ueda, K Higashi, M Kataoka, S Yamashita, K Yamamoto, K Moribe European Journal of Pharmaceutical Sciences 62, 293-300, 2014 | 41 | 2014 |
Equilibrium State at Supersaturated Drug Concentration Achieved by Hydroxypropyl Methylcellulose Acetate Succinate: Molecular Characterization Using 1H NMR … K Ueda, K Higashi, K Yamamoto, K Moribe Molecular pharmaceutics 12 (4), 1096-1104, 2015 | 40 | 2015 |
Impact of hypromellose acetate succinate grade on drug amorphous solubility and in vitro membrane transport K Ueda, SS Hate, LS Taylor Journal of pharmaceutical sciences 109 (8), 2464-2473, 2020 | 38 | 2020 |
Effect of Drug-Polymer Interactions through Hypromellose Acetate Succinate Substituents on the Physical Stability on Solid Dispersions Studied by Fourier-Transform Infrared and … Y Ishizuka, K Ueda, H Okada, J Takeda, M Karashima, K Yazawa, ... Molecular pharmaceutics 16 (6), 2785-2794, 2019 | 38 | 2019 |
Cryo-TEM and AFM observation of the time-dependent evolution of amorphous probucol nanoparticles formed by the aqueous dispersion of ternary solid dispersions Z Zhao, H Katai, K Higashi, K Ueda, K Kawakami, K Moribe Molecular pharmaceutics 16 (5), 2184-2198, 2019 | 37 | 2019 |
Mechanism of enhanced nifedipine dissolution by polymer-blended solid dispersion through molecular-level characterization K Ueda, C Yamazoe, Y Yasuda, K Higashi, K Kawakami, K Moribe Molecular pharmaceutics 15 (9), 4099-4109, 2018 | 37 | 2018 |
Molecular mobility suppression of ibuprofen-rich amorphous nanodroplets by HPMC revealed by NMR relaxometry and its significance with respect to crystallization inhibition K Ueda, N Yamamoto, K Higashi, K Moribe Molecular Pharmaceutics 16 (12), 4968-4977, 2019 | 35 | 2019 |
Drug solubilization mechanism of α-glucosyl stevia by NMR spectroscopy J Zhang, K Higashi, K Ueda, K Kadota, Y Tozuka, W Limwikrant, ... International journal of pharmaceutics 465 (1-2), 255-261, 2014 | 34 | 2014 |
Mechanistic elucidation of formation of drug-rich amorphous nanodroplets by dissolution of the solid dispersion formulation K Ueda, K Higashi, K Moribe International journal of pharmaceutics 561, 82-92, 2019 | 32 | 2019 |