Christoph Helma
Christoph Helma
in silico toxicology gmbh
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Data mining and machine learning techniques for the identification of mutagenicity inducing substructures and structure activity relationships of noncongeneric compounds
C Helma, T Cramer, S Kramer, L De Raedt
Journal of chemical information and computer sciences 44 (4), 1402-1411, 2004
Molecular feature mining in HIV data
S Kramer, L De Raedt, C Helma
Proceedings of the seventh ACM SIGKDD international conference on Knowledge …, 2001
The predictive toxicology challenge 2000–2001
C Helma, RD King, S Kramer, A Srinivasan
Bioinformatics 17 (1), 107-108, 2001
Genotoxic effects of heavy metals: comparative investigation with plant bioassays
H Steinkellner, K Mun‐Sik, C Helma, S Ecker, TH Ma, O Horak, M Kundi, ...
Environmental and molecular mutagenesis 31 (2), 183-191, 1998
A public domain image-analysis program for the single-cell gel-electrophoresis (comet) assay
C Helma, M Uhl
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 466 (1), 9-15, 2000
Statistical evaluation of the predictive toxicology challenge 2000–2001
H Toivonen, A Srinivasan, RD King, S Kramer, C Helma
Bioinformatics 19 (10), 1183-1193, 2003
Evaluation of the single cell gel electrophoresis assay with human hepatoma (Hep G2) cells
M Uhl, C Helma, S Knasmüller
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 468 (2 …, 2000
lazar: a modular predictive toxicology framework
A Maunz, M Gütlein, M Rautenberg, D Vorgrimmler, D Gebele, C Helma
Frontiers in Pharmacology 4 (38), 2013
Data quality in predictive toxicology: reproducibility of rodent carcinogenicity experiments.
E Gottmann, S Kramer, B Pfahringer, C Helma
Environmental health perspectives 109 (5), 509-514, 2001
Lazy structure-activity relationships (lazar) for the prediction of rodent carcinogenicity and Salmonella mutagenicity
C Helma
Molecular diversity 10 (2), 147-158, 2006
Single-cell gel electrophoresis assays with human-derived hepatoma (Hep G2) cells
M Uhl, C Helma, S Knasmüller
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 441 (2 …, 1999
Collaborative development of predictive toxicology applications
B Hardy, N Douglas, C Helma, M Rautenberg, N Jeliazkova, V Jeliazkov, ...
Journal of cheminformatics 2, 1-29, 2010
Predictive models for carcinogenicity and mutagenicity: frameworks, state-of-the-art, and perspectives
E Benfenati, R Benigni, DM Demarini, C Helma, D Kirkland, TM Martin, ...
Journal of Environmental Science and Health Part C 27 (2), 57-90, 2009
The expanding role of predictive toxicology: an update on the (Q) SAR models for mutagens and carcinogens
R Benigni, TI Netzeva, E Benfenati, C Bossa, R Franke, C Helma, ...
Journal of Environmental Science and Health Part C 25 (1), 53-97, 2007
Chemoprotective effects of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo [4, 5-f] quinoline (IQ)-induced genotoxic effects and colonic …
F Kassie, S Rabot, M Uhl, W Huber, HM Qin, C Helma, ...
Carcinogenesis 23 (7), 1155-1161, 2002
Prediction of adverse drug reactions using decision tree modeling
F Hammann, H Gutmann, N Vogt, C Helma, J Drewe
Clinical Pharmacology & Therapeutics 88 (1), 52-59, 2010
Knowledge discovery and data mining in toxicology
C Helma, E Gottmann, S Kramer
Statistical methods in medical research 9 (4), 329-358, 2000
Toxic effects of griseofulvin: disease models, mechanisms, and risk assessment
S Knasmüller, W Parzefall, C Helma, F Kassie, S Ecker, ...
Critical reviews in toxicology 27 (5), 495-537, 1997
Comparative evaluation of four bacterial assays for the detection of genotoxic effects in the dissolved water phases of aqueous matrices
C Helma, V Mersch-Sundermann, VS Houk, U Glasbrenner, C Klein, ...
Environmental science & technology 30 (3), 897-907, 1996
Stochastic propositionalization of non-determinate background knowledge
S Kramer, B Pfahringer, C Helma
International Conference on Inductive Logic Programming, 80-94, 1998
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