|SOSUI: classification and secondary structure prediction system for membrane proteins.|
T Hirokawa, S Boon-Chieng, S Mitaku
Bioinformatics (Oxford, England) 14 (4), 378-379, 1998
|Ubiquitin is phosphorylated by PINK1 to activate parkin|
F Koyano, K Okatsu, H Kosako, Y Tamura, E Go, M Kimura, Y Kimura, ...
Nature 510 (7503), 162-166, 2014
|Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site|
S Katada, T Hirokawa, Y Oka, M Suwa, K Touhara
Journal of Neuroscience 25 (7), 1806-1815, 2005
|Amphiphilicity index of polar amino acids as an aid in the characterization of amino acid preference at membrane–water interfaces|
S Mitaku, T Hirokawa, T Tsuji
Bioinformatics 18 (4), 608-616, 2002
|Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands|
K Kawajiri, Y Kobayashi, F Ohtake, T Ikuta, Y Matsushima, J Mimura, ...
Proceedings of the national academy of sciences 106 (32), 13481-13486, 2009
|Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants|
K Nishikawa, H Li, R Kawamura, H Osaka, YL Wang, Y Hara, T Hirokawa, ...
Biochemical and biophysical research communications 304 (1), 176-183, 2003
|Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival|
H Koshimizu, K Kiyosue, T Hara, S Hazama, S Suzuki, K Uegaki, ...
Molecular brain 2 (1), 1-19, 2009
|Analysis of multiple compound–protein interactions reveals novel bioactive molecules|
H Yabuuchi, S Niijima, H Takematsu, T Ida, T Hirokawa, T Hara, T Ogawa, ...
Molecular systems biology 7 (1), 472, 2011
|Physicochemical factors for discriminating between soluble and membrane proteins: hydrophobicity of helical segments and protein length|
S Mitaku, T Hirokawa
Protein engineering 12 (11), 953-957, 1999
|Proportion of membrane proteins in proteomes of 15 single-cell organisms analyzed by the SOSUI prediction system|
S Mitaku, M Ono, T Hirokawa, S Boon-Chieng, M Sonoyama
Biophysical chemistry 82 (2-3), 165-171, 1999
|GRIFFIN: a system for predicting GPCR–G-protein coupling selectivity using a support vector machine and a hidden Markov model|
Y Yabuki, T Muramatsu, T Hirokawa, H Mukai, M Suwa
Nucleic Acids Research 33 (suppl_2), W148-W153, 2005
|Engineering PQQ glucose dehydrogenase with improved substrate specificity: site-directed mutagenesis studies on the active center of PQQ glucose dehydrogenase|
S Igarashi, T Hirokawa, K Sode
Biomolecular engineering 21 (2), 81-89, 2004
|Protein structure prediction using a variety of profile libraries and 3D verification|
K Tomii, T Hirokawa, C Motono
Proteins: Structure, Function, and Bioinformatics 61 (S7), 114-121, 2005
|Molecular mechanisms for sweet-suppressing effect of gymnemic acids|
K Sanematsu, Y Kusakabe, N Shigemura, T Hirokawa, S Nakamura, ...
Journal of Biological Chemistry 289 (37), 25711-25720, 2014
|Substrate specificity of microbial transglutaminase as revealed by three-dimensional docking simulation and mutagenesis|
U Tagami, N Shimba, M Nakamura, K Yokoyama, E Suzuki, T Hirokawa
Protein Engineering, Design & Selection 22 (12), 747-752, 2009
|RCAI-56, a carbocyclic analogue of KRN7000: its synthesis and potent activity for natural killer (NK) T cells to preferentially produce interferon-γ|
T Tashiro, R Nakagawa, T Hirokawa, S Inoue, H Watarai, M Taniguchi, ...
Tetrahedron letters 48 (19), 3343-3347, 2007
|Ligand binding to human prostaglandin E receptor EP 4 at the lipid-bilayer interface|
Y Toyoda, K Morimoto, R Suno, S Horita, K Yamashita, K Hirata, ...
Nature Chemical Biology 15 (1), 18-26, 2019
|Site-specific interaction mapping of phosphorylated ubiquitin to uncover Parkin activation|
K Yamano, BB Queliconi, F Koyano, Y Saeki, T Hirokawa, K Tanaka, ...
Journal of Biological Chemistry 290 (42), 25199-25211, 2015
|Temperature-sensitive substrate and product binding underlie temperature-compensated phosphorylation in the clock|
Y Shinohara, YM Koyama, M Ukai-Tadenuma, T Hirokawa, M Kikuchi, ...
Molecular cell 67 (5), 783-798. e20, 2017
|Investigation of the Bioactive Conformation of Histamine H3 Receptor Antagonists by the Cyclopropylic Strain-Based Conformational Restriction Strategy|
M Watanabe, T Hirokawa, T Kobayashi, A Yoshida, Y Ito, S Yamada, ...
Journal of medicinal chemistry 53 (9), 3585-3593, 2010