Takatsugu Hirokawa
Takatsugu Hirokawa
Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)
Verified email at aist.go.jp
Title
Cited by
Cited by
Year
SOSUI: classification and secondary structure prediction system for membrane proteins.
T Hirokawa, S Boon-Chieng, S Mitaku
Bioinformatics (Oxford, England) 14 (4), 378-379, 1998
20551998
Ubiquitin is phosphorylated by PINK1 to activate parkin
F Koyano, K Okatsu, H Kosako, Y Tamura, E Go, M Kimura, Y Kimura, ...
Nature 510 (7503), 162-166, 2014
9102014
Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site
S Katada, T Hirokawa, Y Oka, M Suwa, K Touhara
Journal of Neuroscience 25 (7), 1806-1815, 2005
3062005
Amphiphilicity index of polar amino acids as an aid in the characterization of amino acid preference at membrane–water interfaces
S Mitaku, T Hirokawa, T Tsuji
Bioinformatics 18 (4), 608-616, 2002
2182002
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
K Kawajiri, Y Kobayashi, F Ohtake, T Ikuta, Y Matsushima, J Mimura, ...
Proceedings of the national academy of sciences 106 (32), 13481-13486, 2009
2022009
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants
K Nishikawa, H Li, R Kawamura, H Osaka, YL Wang, Y Hara, T Hirokawa, ...
Biochemical and biophysical research communications 304 (1), 176-183, 2003
1742003
Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
H Koshimizu, K Kiyosue, T Hara, S Hazama, S Suzuki, K Uegaki, ...
Molecular brain 2 (1), 1-19, 2009
1682009
Analysis of multiple compound–protein interactions reveals novel bioactive molecules
H Yabuuchi, S Niijima, H Takematsu, T Ida, T Hirokawa, T Hara, T Ogawa, ...
Molecular systems biology 7 (1), 472, 2011
1432011
Physicochemical factors for discriminating between soluble and membrane proteins: hydrophobicity of helical segments and protein length
S Mitaku, T Hirokawa
Protein engineering 12 (11), 953-957, 1999
971999
Proportion of membrane proteins in proteomes of 15 single-cell organisms analyzed by the SOSUI prediction system
S Mitaku, M Ono, T Hirokawa, S Boon-Chieng, M Sonoyama
Biophysical chemistry 82 (2-3), 165-171, 1999
761999
GRIFFIN: a system for predicting GPCR–G-protein coupling selectivity using a support vector machine and a hidden Markov model
Y Yabuki, T Muramatsu, T Hirokawa, H Mukai, M Suwa
Nucleic Acids Research 33 (suppl_2), W148-W153, 2005
662005
Engineering PQQ glucose dehydrogenase with improved substrate specificity: site-directed mutagenesis studies on the active center of PQQ glucose dehydrogenase
S Igarashi, T Hirokawa, K Sode
Biomolecular engineering 21 (2), 81-89, 2004
662004
Protein structure prediction using a variety of profile libraries and 3D verification
K Tomii, T Hirokawa, C Motono
Proteins: Structure, Function, and Bioinformatics 61 (S7), 114-121, 2005
502005
Molecular mechanisms for sweet-suppressing effect of gymnemic acids
K Sanematsu, Y Kusakabe, N Shigemura, T Hirokawa, S Nakamura, ...
Journal of Biological Chemistry 289 (37), 25711-25720, 2014
492014
Substrate specificity of microbial transglutaminase as revealed by three-dimensional docking simulation and mutagenesis
U Tagami, N Shimba, M Nakamura, K Yokoyama, E Suzuki, T Hirokawa
Protein Engineering, Design & Selection 22 (12), 747-752, 2009
482009
RCAI-56, a carbocyclic analogue of KRN7000: its synthesis and potent activity for natural killer (NK) T cells to preferentially produce interferon-γ
T Tashiro, R Nakagawa, T Hirokawa, S Inoue, H Watarai, M Taniguchi, ...
Tetrahedron letters 48 (19), 3343-3347, 2007
482007
Ligand binding to human prostaglandin E receptor EP 4 at the lipid-bilayer interface
Y Toyoda, K Morimoto, R Suno, S Horita, K Yamashita, K Hirata, ...
Nature Chemical Biology 15 (1), 18-26, 2019
442019
Site-specific interaction mapping of phosphorylated ubiquitin to uncover Parkin activation
K Yamano, BB Queliconi, F Koyano, Y Saeki, T Hirokawa, K Tanaka, ...
Journal of Biological Chemistry 290 (42), 25199-25211, 2015
432015
Temperature-sensitive substrate and product binding underlie temperature-compensated phosphorylation in the clock
Y Shinohara, YM Koyama, M Ukai-Tadenuma, T Hirokawa, M Kikuchi, ...
Molecular cell 67 (5), 783-798. e20, 2017
412017
Investigation of the Bioactive Conformation of Histamine H3 Receptor Antagonists by the Cyclopropylic Strain-Based Conformational Restriction Strategy
M Watanabe, T Hirokawa, T Kobayashi, A Yoshida, Y Ito, S Yamada, ...
Journal of medicinal chemistry 53 (9), 3585-3593, 2010
402010
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