Complete biosynthetic pathway of anditomin: nature’s sophisticated synthetic route to a complex fungal meroterpenoid Y Matsuda, T Wakimoto, T Mori, T Awakawa, I Abe Journal of the American Chemical Society 136 (43), 15326-15336, 2014 | 163 | 2014 |
Pentaketide resorcylic acid synthesis by type III polyketide synthase from Neurospora crassa N Funa, T Awakawa, S Horinouchi Journal of biological chemistry 282 (19), 14476-14481, 2007 | 147 | 2007 |
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont T Wakimoto, Y Egami, Y Nakashima, Y Wakimoto, T Mori, T Awakawa, ... Nature chemical biology 10 (8), 648-655, 2014 | 139 | 2014 |
Physically discrete β-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase T Awakawa, K Yokota, N Funa, F Doi, N Mori, H Watanabe, S Horinouchi Chemistry & biology 16 (6), 613-623, 2009 | 138 | 2009 |
Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides L Zhang, T Hashimoto, B Qin, J Hashimoto, I Kozone, T Kawahara, ... Angewandte Chemie International Edition 56 (7), 1740-1745, 2017 | 133 | 2017 |
Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis Y Matsuda, T Awakawa, T Wakimoto, I Abe Journal of the American Chemical Society 135 (30), 10962-10965, 2013 | 125 | 2013 |
Reconstituted biosynthesis of fungal meroterpenoid andrastin A Y Matsuda, T Awakawa, I Abe Tetrahedron 69 (38), 8199-8204, 2013 | 118 | 2013 |
Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality GCA Amos, T Awakawa, RN Tuttle, AC Letzel, MC Kim, Y Kudo, W Fenical, ... Proceedings of the National Academy of Sciences 114 (52), E11121-E11130, 2017 | 113 | 2017 |
Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase Y Matsuda, T Iwabuchi, T Wakimoto, T Awakawa, I Abe Journal of the American Chemical Society 137 (9), 3393-3401, 2015 | 109 | 2015 |
Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum Y Matsuda, T Iwabuchi, T Fujimoto, T Awakawa, Y Nakashima, T Mori, ... Journal of the American Chemical Society 138 (38), 12671-12677, 2016 | 105 | 2016 |
Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility Y Yan, J Chen, L Zhang, Q Zheng, Y Han, H Zhang, D Zhang, T Awakawa, ... Angewandte Chemie 125 (47), 12534-12538, 2013 | 93 | 2013 |
Terretonin biosynthesis requires methylation as essential step for cyclization Y Matsuda, T Awakawa, T Itoh, T Wakimoto, T Kushiro, I Fujii, Y Ebizuka, ... ChemBioChem 13 (12), 1738-1741, 2012 | 88 | 2012 |
A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis T Awakawa, L Zhang, T Wakimoto, S Hoshino, T Mori, T Ito, J Ishikawa, ... Journal of the American Chemical Society 136 (28), 9910-9913, 2014 | 81 | 2014 |
Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis A Miyanaga, N Funa, T Awakawa, S Horinouchi Proceedings of the National Academy of Sciences 105 (3), 871-876, 2008 | 81 | 2008 |
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis JM Lv, D Hu, H Gao, T Kushiro, T Awakawa, GD Chen, CX Wang, I Abe, ... Nature communications 8 (1), 1644, 2017 | 80 | 2017 |
Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium L. J Sun, T Awakawa, H Noguchi, I Abe Bioorganic & medicinal chemistry letters 22 (20), 6397-6400, 2012 | 80 | 2012 |
Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum Y Araki, T Awakawa, M Matsuzaki, R Cho, Y Matsuda, S Hoshino, ... Proceedings of the National Academy of Sciences 116 (17), 8269-8274, 2019 | 78 | 2019 |
Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis Y Nakashima, T Mori, H Nakamura, T Awakawa, S Hoshino, M Senda, ... Nature communications 9 (1), 104, 2018 | 67 | 2018 |
Pyranonigrin E: a PKS-NRPS hybrid metabolite from Aspergillus niger identified by genome mining T Awakawa, XL Yang, T Wakimoto, I Abe Chembiochem: a European journal of chemical biology 14 (16), 2095-2099, 2013 | 66 | 2013 |
Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823 S Hoshino, L Zhang, T Awakawa, T Wakimoto, H Onaka, I Abe The Journal of Antibiotics 68 (5), 342-344, 2015 | 65 | 2015 |