| Wild-type microglia extend survival in PU. 1 knockout mice with familial amyotrophic lateral sclerosis DR Beers, JS Henkel, Q Xiao, W Zhao, J Wang, AA Yen, L Siklos, ... Proceedings of the National Academy of Sciences 103 (43), 16021-16026, 2006 | 868 | 2006 |
| CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS DR Beers, JS Henkel, W Zhao, J Wang, SH Appel Proceedings of the National Academy of Sciences 105 (40), 15558-15563, 2008 | 511 | 2008 |
| Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS B Liao, W Zhao, DR Beers, JS Henkel, SH Appel Experimental neurology 237 (1), 147-152, 2012 | 446 | 2012 |
| Microglia in ALS: the good, the bad, and the resting JS Henkel, DR Beers, W Zhao, SH Appel Journal of neuroimmune pharmacology 4, 389-398, 2009 | 409 | 2009 |
| Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis DR Beers, JS Henkel, W Zhao, J Wang, A Huang, S Wen, B Liao, ... Brain 134 (5), 1293-1314, 2011 | 408 | 2011 |
| Regulatory T‐lymphocytes mediate amyotrophic lateral sclerosis progression and survival JS Henkel, DR Beers, S Wen, AL Rivera, KM Toennis, JE Appel, W Zhao, ... EMBO molecular medicine 5 (1), 64-79, 2013 | 349 | 2013 |
| Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis W Zhao, DR Beers, SH Appel Journal of Neuroimmune Pharmacology 8, 888-899, 2013 | 341 | 2013 |
| Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury W Zhao, DR Beers, JS Henkel, W Zhang, M Urushitani, JP Julien, ... Glia 58 (2), 231-243, 2010 | 309 | 2010 |
| Protective and toxic neuroinflammation in amyotrophic lateral sclerosis KG Hooten, DR Beers, W Zhao, SH Appel Neurotherapeutics 12 (2), 364-375, 2015 | 291 | 2015 |
| The microglial-motoneuron dialogue in ALS SH Appel, W Zhao, DR Beers, JS Henkel Acta Myologica 30 (1), 4, 2011 | 244 | 2011 |
| TDP-43 activates microglia through NF-κB and NLRP3 inflammasome W Zhao, DR Beers, S Bell, J Wang, S Wen, RH Baloh, SH Appel Experimental Neurology 273, 24-35, 2015 | 224 | 2015 |
| ALS patients’ regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity DR Beers, W Zhao, J Wang, X Zhang, S Wen, D Neal, JR Thonhoff, ... JCI insight 2 (5), 2017 | 201 | 2017 |
| Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice DR Beers, W Zhao, B Liao, O Kano, J Wang, A Huang, SH Appel, ... Brain, behavior, and immunity 25 (5), 1025-1035, 2011 | 199 | 2011 |
| Protective effects of an anti‐inflammatory cytokine, interleukin‐4, on motoneuron toxicity induced by activated microglia W Zhao, W Xie, Q Xiao, DR Beers, SH Appel Journal of neurochemistry 99 (4), 1176-1187, 2006 | 199 | 2006 |
| Mutant SOD1G93A microglia are more neurotoxic relative to wild‐type microglia Q Xiao, W Zhao, DR Beers, AA Yen, W Xie, JS Henkel, SH Appel Journal of neurochemistry 102 (6), 2008-2019, 2007 | 194 | 2007 |
| Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism W Zhao, W Xie, W Le, DR Beers, Y He, JS Henkel, EP Simpson, AA Yen, ... Journal of Neuropathology & Experimental Neurology 63 (9), 964-977, 2004 | 193 | 2004 |
| Characterization of gene expression phenotype in amyotrophic lateral sclerosis monocytes W Zhao, DR Beers, KG Hooten, DH Sieglaff, A Zhang, ... JAMA neurology 74 (6), 677-685, 2017 | 149 | 2017 |
| Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study JR Thonhoff, DR Beers, W Zhao, M Pleitez, EP Simpson, JD Berry, ... Neurology: Neuroimmunology & Neuroinflammation 5 (4), e465, 2018 | 142 | 2018 |
| Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms W Zhao, DR Beers, B Liao, JS Henkel, SH Appel Neurobiology of disease 48 (3), 418-428, 2012 | 137 | 2012 |
| Restoring regulatory T-cell dysfunction in Alzheimer’s disease through ex vivo expansion A Faridar, AD Thome, W Zhao, JR Thonhoff, DR Beers, B Pascual, ... Brain communications 2 (2), fcaa112, 2020 | 57 | 2020 |
