Structure/function characterization of μ-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels MM Zhang, BR Green, P Catlin, B Fiedler, L Azam, A Chadwick, H Terlau, ... Journal of Biological Chemistry 282 (42), 30699-30706, 2007 | 164 | 2007 |
Marine toxins that target voltage-gated sodium channels A Al-Sabi, J McArthur, V Ostroumov, RJ French Marine Drugs 4 (3), 157-192, 2006 | 84 | 2006 |
Dicarba α-Conotoxin Vc1.1 Analogues with Differential Selectivity for Nicotinic Acetylcholine and GABAB Receptors BJ Van Lierop, SD Robinson, SN Kompella, A Belgi, JR McArthur, A Hung, ... ACS chemical biology 8 (8), 1815-1821, 2013 | 79 | 2013 |
Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? O Knapp, JR McArthur, DJ Adams Toxins 4 (11), 1236-1260, 2012 | 67 | 2012 |
Unexpected synergism between tetrodotoxin and μ-conotoxin in blocking voltage-gated sodium channels MM Zhang, JR McArthur, L Azam, G Bulaj, BM Olivera, RJ French, ... Channels 3 (1), 32-38, 2009 | 59 | 2009 |
Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA JR McArthur, G Singh, D McMaster, R Winkfein, DP Tieleman, RJ French Molecular pharmacology 80 (4), 573-584, 2011 | 54 | 2011 |
Modulation of KvAP unitary conductance and gating by 1-alkanols and other surface active agents RK Finol-Urdaneta, JR McArthur, PF Juranka, RJ French, CE Morris Biophysical journal 98 (5), 762-772, 2010 | 45 | 2010 |
Differential Cav2. 1 and Cav2. 3 channel inhibition by baclofen and α-conotoxin Vc1. 1 via GABAB receptor activation G Berecki, JR McArthur, H Cuny, RJ Clark, DJ Adams Biophysical Journal 106 (2), 330a, 2014 | 44 | 2014 |
Marine toxins targeting Kv1 channels: Pharmacological tools and therapeutic scaffolds RK Finol-Urdaneta, A Belovanovic, M Micic-Vicovac, GK Kinsella, ... Marine drugs 18 (3), 173, 2020 | 40 | 2020 |
Multiple, distributed interactions of μ-conotoxin PIIIA associated with broad targeting among voltage-gated sodium channels JR McArthur, V Ostroumov, A Al-Sabi, D McMaster, RJ French Biochemistry 50 (1), 116-124, 2011 | 37 | 2011 |
Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons M Sadeghi, JR McArthur, RK Finol-Urdaneta, DJ Adams Neuropharmacology 127, 116-123, 2017 | 34 | 2017 |
Orientation of μ-conotoxin PIIIA in a sodium channel vestibule, based on voltage dependence of its binding JR McArthur, G Singh, ML O'Mara, D McMaster, V Ostroumov, ... Molecular Pharmacology 80 (2), 219-227, 2011 | 31 | 2011 |
Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides SR Sousa, JR McArthur, A Brust, RF Bhola, KJ Rosengren, L Ragnarsson, ... Scientific reports 8 (1), 13397, 2018 | 28 | 2018 |
ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels CE Tranberg, A Yang, I Vette, JR McArthur, JB Baell, RJ Lewis, KL Tuck, ... Marine Drugs 10 (10), 2349-2368, 2012 | 23 | 2012 |
Molecular and functional characterization of neurogenin-2 induced human sensory neurons AJ Hulme, JR McArthur, S Maksour, S Miellet, L Ooi, DJ Adams, ... Frontiers in Cellular Neuroscience 14, 600895, 2020 | 21 | 2020 |
Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels RK Finol-Urdaneta, JR McArthur, MP Goldschen-Ohm, R Gaudet, ... Journal of General Physiology 151 (2), 186-199, 2019 | 21 | 2019 |
Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis JP Torres, Z Lin, M Watkins, PF Salcedo, RP Baskin, S Elhabian, ... Science advances 7 (11), eabf2704, 2021 | 20 | 2021 |
Analgesic transient receptor potential vanilloid‐1‐active compounds inhibit native and recombinant T‐type calcium channels JR McArthur, RK Finol‐Urdaneta, DJ Adams British Journal of Pharmacology 176 (13), 2264-2278, 2019 | 18 | 2019 |
Extremely potent block of bacterial voltage-gated sodium channels by µ-conotoxin PIIIA RK Finol-Urdaneta, JR McArthur, VS Korkosh, S Huang, D McMaster, ... Marine drugs 17 (9), 510, 2019 | 14 | 2019 |
Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider RK Finol-Urdaneta, R Ziegman, Z Dekan, JR McArthur, S Heitmann, ... Proceedings of the National Academy of Sciences 119 (5), e2110932119, 2022 | 13 | 2022 |