| Widespread seasonal gene expression reveals annual differences in human immunity and physiology XC Dopico, M Evangelou, RC Ferreira, H Guo, ML Pekalski, DJ Smyth, ... Nature communications 6 (1), 7000, 2015 | 517 | 2015 |
| A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes RC Ferreira, H Guo, RMR Coulson, DJ Smyth, ML Pekalski, OS Burren, ... Diabetes 63 (7), 2538-2550, 2014 | 319 | 2014 |
| Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases RC Ferreira, DF Freitag, AJ Cutler, JMM Howson, DB Rainbow, DJ Smyth, ... PLoS genetics 9 (4), e1003444, 2013 | 307 | 2013 |
| Standardizing flow cytometry immunophenotyping analysis from the human immunophenotyping consortium G Finak, M Langweiler, M Jaimes, M Malek, J Taghiyar, Y Korin, ... Scientific reports 6 (1), 1-11, 2016 | 306 | 2016 |
| Epithelial–mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease KA Rygiel, H Robertson, HL Marshall, M Pekalski, L Zhao, TA Booth, ... Laboratory investigation 88 (2), 112-123, 2008 | 306 | 2008 |
| Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+ CD25+ regulatory T cell function G Garg, JR Tyler, JHM Yang, AJ Cutler, K Downes, M Pekalski, GL Bell, ... The Journal of Immunology 188 (9), 4644-4653, 2012 | 253 | 2012 |
| IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients RC Ferreira, HZ Simons, WS Thompson, AJ Cutler, XC Dopico, DJ Smyth, ... Diabetologia 58, 781-790, 2015 | 155 | 2015 |
| Regulatory T cell responses in participants with type 1 diabetes after a single dose of interleukin-2: a non-randomised, open label, adaptive dose-finding trial JA Todd, M Evangelou, AJ Cutler, ML Pekalski, NM Walker, HE Stevens, ... PLoS medicine 13 (10), e1002139, 2016 | 148 | 2016 |
| The human mitochondrial ribosome recycling factor is essential for cell viability J Rorbach, R Richter, HJ Wessels, M Wydro, M Pekalski, M Farhoud, ... Nucleic acids research 36 (18), 5787-5799, 2008 | 141 | 2008 |
| A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease LB Peterson, CJM Bell, SK Howlett, ML Pekalski, K Brady, H Hinton, ... Journal of autoimmunity 95, 1-14, 2018 | 136 | 2018 |
| Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs PA Gammage, E Gaude, L Van Haute, P Rebelo-Guiomar, CB Jackson, ... Nucleic acids research 44 (16), 7804-7816, 2016 | 122 | 2016 |
| Reduced expression of IFIH1 is protective for type 1 diabetes K Downes, M Pekalski, KL Angus, M Hardy, S Nutland, DJ Smyth, ... PloS one 5 (9), e12646, 2010 | 114 | 2010 |
| Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells CJM Bell, Y Sun, UM Nowak, J Clark, S Howlett, ML Pekalski, X Yang, ... Journal of Autoimmunity 56, 66-80, 2015 | 96 | 2015 |
| Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity RC Ferreira, HZ Simons, WS Thompson, DB Rainbow, X Yang, AJ Cutler, ... Journal of Autoimmunity 84, 75-86, 2017 | 88 | 2017 |
| Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors ML Pekalski, RC Ferreira, RMR Coulson, AJ Cutler, H Guo, DJ Smyth, ... The Journal of Immunology 190 (6), 2554-2566, 2013 | 70 | 2013 |
| Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes WS Thompson, ML Pekalski, HZ Simons, DJ Smyth, X Castro-Dopico, ... Clinical & Experimental Immunology 177 (3), 571-585, 2014 | 69 | 2014 |
| Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2 ML Pekalski, AR García, RC Ferreira, DB Rainbow, DJ Smyth, M Mashar, ... JCI insight 2 (16), 2017 | 67 | 2017 |
| Dissection of a complex disease susceptibility region using a Bayesian stochastic search approach to fine mapping C Wallace, AJ Cutler, N Pontikos, ML Pekalski, OS Burren, JD Cooper, ... PLoS genetics 11 (6), e1005272, 2015 | 65 | 2015 |
| Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles L Esposito, K Hunter, J Clark, DB Rainbow, H Stevens, J Denesha, ... The Journal of Immunology 193 (2), 889-900, 2014 | 48 | 2014 |
| The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes E Seelig, J Howlett, L Porter, L Truman, J Heywood, J Kennet, EL Arbon, ... JCI insight 3 (19), 2018 | 43 | 2018 |
