Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ... Nature biotechnology 34 (2), 184-191, 2016 | 3814 | 2016 |
A next generation connectivity map: L1000 platform and the first 1,000,000 profiles A Subramanian, R Narayan, SM Corsello, DD Peck, TE Natoli, X Lu, ... Cell 171 (6), 1437-1452. e17, 2017 | 2569 | 2017 |
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation JG Doench, E Hartenian, DB Graham, Z Tothova, M Hegde, I Smith, ... Nature biotechnology 32 (12), 1262-1267, 2014 | 1757 | 2014 |
Data-analysis strategies for image-based cell profiling JC Caicedo, S Cooper, F Heigwer, S Warchal, P Qiu, C Molnar, ... Nature methods 14 (9), 849-863, 2017 | 627 | 2017 |
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico AL Williams, SBR Jacobs, H Moreno-Macías, A Huerta-Chagoya, ... Nature 506 (7486), 97-101, 2014 | 558 | 2014 |
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map I Smith, PG Greenside, T Natoli, DL Lahr, D Wadden, I Tirosh, R Narayan, ... PLoS biology 15 (11), e2003213, 2017 | 205 | 2017 |
In Silico Predictive Modeling of CRISPR/Cas9 guide efficiency N Fusi, I Smith, J Doench, J Listgarten BioRxiv, 021568, 2015 | 54 | 2015 |
Modeling cellular response in large-scale radiogenomic databases to advance precision radiotherapy VSK Manem, M Lambie, I Smith, P Smirnov, V Kofia, M Freeman, ... Cancer research 79 (24), 6227-6237, 2019 | 28 | 2019 |
Evaluation of statistical approaches for association testing in noisy drug screening data P Smirnov, I Smith, Z Safikhani, W Ba-Alawi, F Khodakarami, E Lin, Y Yu, ... BMC bioinformatics 23 (1), 188, 2022 | 11 | 2022 |
Integrative cancer pharmacogenomics to establish drug mechanism of action: drug repurposing N El-Hachem, W Ba-Alawi, I Smith, AS Mer, B Haibe-Kains Pharmacogenomics 18 (16), 1469-1472, 2017 | 5 | 2017 |
Similarity metric learning on perturbational datasets improves functional identification of perturbations I Smith, P Smirnov, B Haibe-Kains bioRxiv, 2023.06. 09.544397, 2023 | 1 | 2023 |
Meta-analysis of preclinical pharmacogenomic studies to discover robust and translatable biomarkers of drug response P Smirnov, SK Nair, F Abbas-Aghababazadeh, N Feizi, I Smith, TJ Pugh, ... bioRxiv, 2022.10. 22.513279, 2022 | 1 | 2022 |
Similarity bias from averaging signatures from the Connectivity Map I Smith, B Haibe-Kains bioRxiv, 2022 | 1 | 2022 |
On the distribution of cosine similarity with application to biology I Smith, J Ortmann, F Abbas-Aghababazadeh, P Smirnov, B Haibe-Kains arXiv preprint arXiv:2310.13994, 2023 | | 2023 |
Detection of circular RNAs and their potential as biomarkers predictive of drug response J Nguyen, A Mammoliti, SK Nair, E So, F Abbas-Aghababazadeh, C Eeles, ... bioRxiv, 2023.01. 08.522775, 2023 | | 2023 |