Carlos Miguel Farinha
Carlos Miguel Farinha
Associate Professor of Biochemistry
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Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin
CM Farinha, MD Amaral
Molecular and cellular biology 25 (12), 5242-5252, 2005
The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator …
CM Farinha, P Nogueira, F Mendes, D Penque, MD Amaral
Biochemical Journal 366 (3), 797-806, 2002
Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction
CM Farinha, J King-Underwood, M Sousa, AR Correia, BJ Henriques, ...
Chemistry & biology 20 (7), 943-955, 2013
Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells
D Penque, F Mendes, S Beck, C Farinha, P Pacheco, P Nogueira, ...
Laboratory investigation 80 (6), 857-868, 2000
Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the Golgi
CM Farinha, P Matos, MD Amaral
The FEBS journal 280 (18), 4396-4406, 2013
Rescuing mutant CFTR: a multi-task approach to a better outcome in treating cystic fibrosis
M D Amaral, C M Farinha
Current pharmaceutical design 19 (19), 3497-3508, 2013
Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation
LS Pissarra, CM Farinha, Z Xu, A Schmidt, PH Thibodeau, Z Cai, ...
Chemistry & biology 15 (1), 62-69, 2008
Cystic fibrosis patients with the 3272‐26A→ G mutation have mild disease, leaky alternative mRNA splicing, and CFTR protein at the cell membrane
S Beck, D Penque, S Garcia, A Gomes, C Farinha, L Mata, S Gulbenkian, ...
Human mutation 14 (2), 133-144, 1999
Measurements of functional responses in human primary lung cells as a basis for personalized therapy for cystic fibrosis
NT Awatade, I Uliyakina, CM Farinha, LA Clarke, K Mendes, A Solé, ...
EBioMedicine 2 (2), 147-153, 2015
From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking
CM Farinha, S Canato
Cellular and Molecular Life Sciences 74 (1), 39-55, 2017
Biochemical methods to assess CFTR expression and membrane localization
CM Farinha, D Penque, M Roxo-Rosa, G Lukacs, R Dormer, ...
Journal of Cystic Fibrosis 3, 73-77, 2004
Cystic fibrosis patients with the 3272-26A> G splicing mutation have milder disease than F508del homozygotes: a large European study
MD Amaral, P Pacheco, S Beck, CM Farinha, D Penque, P Nogueira, ...
Journal of medical genetics 38 (11), 777-783, 2001
Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity
S Luz, P Kongsuphol, AI Mendes, F Romeiras, M Sousa, R Schreiber, ...
Molecular and cellular biology 31 (22), 4392-4404, 2011
EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1
MJ Lobo, MD Amaral, M Zaccolo, CM Farinha
Journal of cell science 129 (13), 2599-2612, 2016
Methods for RNA extraction, cDNA preparation and analysis of CFTR transcripts
AS Ramalho, S Beck, CM Farinha, LA Clarke, GD Heda, B Steiner, J Sanz, ...
Journal of Cystic Fibrosis 3, 11-15, 2004
Antibodies for CFTR studies
F Mendes, CM Farinha, M Roxo-Rosa, P Fanen, A Edelman, R Dormer, ...
Journal of Cystic Fibrosis 3, 69-72, 2004
Increased efficacy of VX‐809 in different cellular systems results from an early stabilization effect of F508del‐CFTR
CM Farinha, M Sousa, S Canato, A Schmidt, I Uliyakina, MD Amaral
Pharmacology research & perspectives 3 (4), e00152, 2015
A comparison of 14 antibodies for the biochemical detection of the cystic fibrosis transmembrane conductance regulator protein
CM Farinha, F Mendes, M Roxo-Rosa, D Penque, MD Amaral
Molecular and cellular probes 18 (4), 235-242, 2004
LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells
S Luz, KM Cihil, DL Brautigan, MD Amaral, CM Farinha, ...
Journal of Biological Chemistry 289 (21), 15080-15093, 2014
Unusually common cystic fibrosis mutation in Portugal encodes a misprocessed protein
F Mendes, MR Rosa, A Dragomir, CM Farinha, GM Roomans, MD Amaral, ...
Biochemical and biophysical research communications 311 (3), 665-671, 2003
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