| Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme K Nakagawa, Y Hirota, N Sawada, N Yuge, M Watanabe, Y Uchino, ... Nature 468 (7320), 117-121, 2010 | 431 | 2010 |
| Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats Y Hirota, N Tsugawa, K Nakagawa, Y Suhara, K Tanaka, Y Uchino, ... Journal of Biological Chemistry 288 (46), 33071-33080, 2013 | 177 | 2013 |
| The UBIAD 1 Prenyltransferase Links Menaquione‐4 Synthesis to Cholesterol Metabolic Enzymes ML Nickerson, AD Bosley, JS Weiss, BN Kostiha, Y Hirota, W Brandt, ... Human mutation 34 (2), 317-329, 2013 | 88 | 2013 |
| Functional Characterization of the Vitamin K2 Biosynthetic Enzyme UBIAD1 Y Hirota, K Nakagawa, N Sawada, N Okuda, Y Suhara, Y Uchino, ... PLoS One 10 (4), e0125737, 2015 | 73 | 2015 |
| Vitamin K2 Biosynthetic Enzyme, UBIAD1 Is Essential for Embryonic Development of Mice K Nakagawa, N Sawada, Y Hirota, Y Uchino, Y Suhara, T Hasegawa, ... PLoS One 9 (8), e104078, 2014 | 67 | 2014 |
| Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines Y Suhara, Y Hirota, K Nakagawa, M Kamao, N Tsugawa, T Okano Bioorganic & medicinal chemistry 16 (6), 3108-3117, 2008 | 36 | 2008 |
| Generation of 1, 25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes M Nishikawa, K Yasuda, M Takamatsu, K Abe, K Nakagawa, N Tsugawa, ... The Journal of Steroid Biochemistry and Molecular Biology 185, 71-79, 2019 | 35 | 2019 |
| New aspects of vitamin K research with synthetic ligands: transcriptional activity via SXR and neural differentiation activity Y Hirota, Y Suhara International journal of molecular sciences 20 (12), 3006, 2019 | 32 | 2019 |
| Acylated anthocyanins derived from purple carrot (Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole A Tsutsumi, Y Horikoshi, T Fushimi, A Saito, R Koizumi, Y Fujii, QQ Hu, ... Food & function 10 (3), 1726-1735, 2019 | 28 | 2019 |
| Divergent mechanisms activating RAS and small GTPases through post-translational modification N Osaka, Y Hirota, D Ito, Y Ikeda, R Kamata, Y Fujii, VR Chirasani, ... Frontiers in Molecular Biosciences 8, 707439, 2021 | 24 | 2021 |
| Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions M Nishikawa, K Yasuda, M Takamatsu, K Abe, K Okamoto, K Horibe, ... Scientific reports 10 (1), 5677, 2020 | 23 | 2020 |
| Synthesis of novel synthetic vitamin K analogues prepared by introduction of a heteroatom and a phenyl group that induce highly selective neuronal differentiation of neuronal … K Kimura, Y Hirota, S Kuwahara, A Takeuchi, C Tode, A Wada, ... Journal of Medicinal Chemistry 60 (6), 2591-2596, 2017 | 23 | 2017 |
| Synthetic small molecules derived from natural vitamin K homologues that induce selective neuronal differentiation of neuronal progenitor cells Y Suhara, Y Hirota, N Hanada, S Nishina, S Eguchi, R Sakane, ... Journal of Medicinal Chemistry 58 (17), 7088-7092, 2015 | 23 | 2015 |
| Nongenomic effects of 1α, 25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice Y Hirota, K Nakagawa, S Mimatsu, N Sawada, T Sakaki, N Kubodera, ... Biochemical and biophysical research communications 483 (1), 359-365, 2017 | 21 | 2017 |
| Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities R Sakane, K Kimura, Y Hirota, M Ishizawa, Y Takagi, A Wada, ... Bioorganic & Medicinal Chemistry Letters 27 (21), 4881-4884, 2017 | 12 | 2017 |
| YY1 positively regulates human UBIAD1 expression N Funahashi, Y Hirota, K Nakagawa, N Sawada, M Watanabe, Y Suhara, ... Biochemical and biophysical research communications 460 (2), 238-244, 2015 | 12 | 2015 |
| Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives T Nishioka, K Endo-Umeda, Y Ito, A Shimoda, A Takeuchi, C Tode, ... Molecules 24 (23), 4316, 2019 | 10 | 2019 |
| Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice M Ito, N Kudo, Y Miyake, T Imai, T Unno, Y Yamashita, Y Hirota, H Ashida, ... Experimental Gerontology 98, 120-123, 2017 | 10 | 2017 |
| Emerging roles of wild-type and mutant IDH1 in growth, metabolism and therapeutics of glioma M Garrett, Y Fujii, N Osaka, D Ito, Y Hirota, A Sasaki Exon Publications, 61-78, 2021 | 9 | 2021 |
| Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity Y Fujii, Y Suhara, Y Sukikara, T Teshima, Y Hirota, K Yoshimura, ... Molecules 24 (20), 3667, 2019 | 9 | 2019 |
