| Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication P Nash, X Tang, S Orlicky, Q Chen, FB Gertler, MD Mendenhall, F Sicheri, ... Nature 414 (6863), 514-521, 2001 | 940 | 2001 |
| Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase S Orlicky, X Tang, A Willems, M Tyers, F Sicheri Cell 112 (2), 243-256, 2003 | 606 | 2003 |
| Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor T Mittag, S Orlicky, WY Choy, X Tang, H Lin, F Sicheri, LE Kay, M Tyers, ... Proceedings of the National Academy of Sciences 105 (46), 17772-17777, 2008 | 364 | 2008 |
| Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase T Mittag, J Marsh, A Grishaev, S Orlicky, H Lin, F Sicheri, M Tyers, ... Structure 18 (4), 494-506, 2010 | 286 | 2010 |
| Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination X Tang, S Orlicky, Z Lin, A Willems, D Neculai, D Ceccarelli, F Mercurio, ... Cell 129 (6), 1165-1176, 2007 | 251 | 2007 |
| An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme DF Ceccarelli, X Tang, B Pelletier, S Orlicky, W Xie, V Plantevin, ... Cell 145 (7), 1075-1087, 2011 | 248 | 2011 |
| OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function YC Juang, MC Landry, M Sanches, V Vittal, CCY Leung, DF Ceccarelli, ... Molecular cell 45 (3), 384-397, 2012 | 207 | 2012 |
| Molecular characterization of a toluene-degrading methanogenic consortium M Ficker, K Krastel, S Orlicky, E Edwards Applied and environmental microbiology 65 (12), 5576-5585, 1999 | 201 | 1999 |
| An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase S Orlicky, X Tang, V Neduva, N Elowe, ED Brown, F Sicheri, M Tyers Nature biotechnology 28 (7), 733-737, 2010 | 161 | 2010 |
| Transcription elongation through DNA arrest sites: a multistep process involving both RNA polymerase II subunit RPB9 and TFIIS DE Awrey, RG Weilbaecher, SA Hemming, SM Orlicky, CM Kane, ... Journal of Biological Chemistry 272 (23), 14747-14754, 1997 | 146 | 1997 |
| Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity H Huang, E Zeqiraj, B Dong, BK Jha, NM Duffy, S Orlicky, ... Molecular cell 53 (2), 221-234, 2014 | 135 | 2014 |
| Dissociable Rpb4-Rpb7 subassembly of RNA polymerase II binds to single-strand nucleic acid and mediates a post-recruitment step in transcription initiation SM Orlicky, PT Tran, MH Sayre, AM Edwards Journal of Biological Chemistry 276 (13), 10097-10102, 2001 | 111 | 2001 |
| Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine DYL Mao, D Neculai, M Downey, S Orlicky, YZ Haffani, DF Ceccarelli, ... Molecular cell 32 (2), 259-275, 2008 | 107 | 2008 |
| Functional characterization of a PROTAC directed against BRAF mutant V600E G Posternak, X Tang, P Maisonneuve, T Jin, H Lavoie, S Daou, S Orlicky, ... Nature chemical biology 16 (11), 1170-1178, 2020 | 95 | 2020 |
| E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin H Huang, DF Ceccarelli, S Orlicky, DJ St-Cyr, A Ziemba, P Garg, ... Nature chemical biology 10 (2), 156-163, 2014 | 93 | 2014 |
| Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface M Gorelik, S Orlicky, MA Sartori, X Tang, E Marcon, I Kurinov, ... Proceedings of the National Academy of Sciences 113 (13), 3527-3532, 2016 | 69 | 2016 |
| Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase X Tang, S Orlicky, T Mittag, V Csizmok, T Pawson, JD Forman-Kay, ... Proceedings of the National Academy of Sciences 109 (9), 3287-3292, 2012 | 67 | 2012 |
| Higher-order assembly of BRCC36–KIAA0157 is required for DUB activity and biological function E Zeqiraj, L Tian, CA Piggott, MC Pillon, NM Duffy, DF Ceccarelli, ... Molecular cell 59 (6), 970-983, 2015 | 52 | 2015 |
| An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase V Csizmok, S Orlicky, J Cheng, J Song, A Bah, N Delgoshaie, H Lin, ... Nature Communications 8 (1), 13943, 2017 | 41 | 2017 |
| Genome‐wide surveys for phosphorylation‐dependent substrates of scf ubiquitin ligases X Tang, S Orlicky, Q Liu, A Willems, F Sicheri, M Tyers Methods in enzymology 399, 433-458, 2005 | 39 | 2005 |
