Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms H Hamamoto, K Kurokawa, C Kaito, K Kamura, I Manitra Razanajatovo, ... Antimicrobial agents and chemotherapy 48 (3), 774-779, 2004 | 245 | 2004 |
Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane H Hamamoto, M Urai, K Ishii, J Yasukawa, A Paudel, M Murai, T Kaji, ... Nature chemical biology 11 (2), 127-133, 2015 | 226 | 2015 |
Antimicrobial action mechanism of flavonoids from Dorstenia species JP Dzoyem, H Hamamoto, B Ngameni, BT Ngadjui, K Sekimizu Drug discoveries & therapeutics 7 (2), 66-72, 2013 | 195 | 2013 |
Silkworm as a model animal to evaluate drug candidate toxicity and metabolism H Hamamoto, A Tonoike, K Narushima, R Horie, K Sekimizu Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology …, 2009 | 171 | 2009 |
Increase in resistance of methicillin-resistant Staphylococcus aureus to β-lactams caused by mutations conferring resistance to benzalkonium chloride, a disinfectant widely … N Akimitsu, H Hamamoto, R Inoue, M Shoji, A Akamine, K Takemori, ... Antimicrobial agents and chemotherapy 43 (12), 3042-3043, 1999 | 151 | 1999 |
A role of the Duffy antigen for the maintenance of plasma chemokine concentrations N Fukuma, N Akimitsu, H Hamamoto, H Kusuhara, Y Sugiyama, ... Biochemical and biophysical research communications 303 (1), 137-139, 2003 | 147 | 2003 |
Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIα N Akimitsu, N Adachi, H Hirai, MS Hossain, H Hamamoto, M Kobayashi, ... Genes to Cells 8 (4), 393-402, 2003 | 119 | 2003 |
Advantages of the silkworm as an animal model for developing novel antimicrobial agents S Panthee, A Paudel, H Hamamoto, K Sekimizu Frontiers in Microbiology 8, 242960, 2017 | 94 | 2017 |
Activation of the silkworm cytokine by bacterial and fungal cell wall components via a reactive oxygen species-triggered mechanism K Ishii, H Hamamoto, M Kamimura, K Sekimizu Journal of Biological Chemistry 283 (4), 2185-2191, 2008 | 94 | 2008 |
Insect cytokine paralytic peptide (PP) induces cellular and humoral immune responses in the silkworm Bombyx mori K Ishii, H Hamamoto, M Kamimura, Y Nakamura, H Noda, K Imamura, ... Journal of biological chemistry 285 (37), 28635-28642, 2010 | 88 | 2010 |
Lysobacter species: a potential source of novel antibiotics S Panthee, H Hamamoto, A Paudel, K Sekimizu Archives of microbiology 198, 839-845, 2016 | 87 | 2016 |
Serratia marcescens suppresses host cellular immunity via the production of an adhesion-inhibitory factor against immunosurveillance cells K Ishii, T Adachi, H Hamamoto, K Sekimizu Journal of Biological Chemistry 289 (9), 5876-5888, 2014 | 86 | 2014 |
A silkworm–baculovirus model for assessing the therapeutic effects of antiviral compounds: characterization and application to the isolation of antivirals from traditional … Y Orihara, H Hamamoto, H Kasuga, T Shimada, Y Kawaguchi, K Sekimizu Journal of general virology 89 (1), 188-194, 2008 | 72 | 2008 |
Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection I Nakamura, R Kanasaki, K Yoshikawa, S Furukawa, A Fujie, ... The Journal of antibiotics 70 (1), 41-44, 2017 | 67 | 2017 |
Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae K Ishii, H Hamamoto, K Imamura, T Adachi, M Shoji, K Nakayama, ... Journal of biological chemistry 285 (43), 33338-33347, 2010 | 59 | 2010 |
Antimicrobial sesquiterpenoids from Laurus nobilis L. N Fukuyama, C Ino, Y Suzuki, N Kobayashi, H Hamamoto, K Sekimizu, ... Natural product research 25 (14), 1295-1303, 2011 | 56 | 2011 |
Lipopolysaccharide O-antigen of enterohemorrhagic Escherichia coli O157:H7 is required for killing both insects and mammals A Miyashita, S Iyoda, K Ishii, H Hamamoto, K Sekimizu, C Kaito FEMS microbiology letters 333 (1), 59-68, 2012 | 54 | 2012 |
Use of silkworm larvae to study pathogenic bacterial toxins MS Hossain, H Hamamoto, Y Matsumoto, IM Razanajatovo, J Larranaga, ... Journal of biochemistry 140 (3), 439-444, 2006 | 53 | 2006 |
Serratia marcescens induces apoptotic cell death in host immune cells via a lipopolysaccharide-and flagella-dependent mechanism K Ishii, T Adachi, K Imamura, S Takano, K Usui, K Suzuki, H Hamamoto, ... Journal of Biological Chemistry 287 (43), 36582-36592, 2012 | 52 | 2012 |
Identification of a Serratia marcescens virulence factor that promotes hemolymph bleeding in the silkworm, Bombyx mori K Ishii, T Adachi, T Hara, H Hamamoto, K Sekimizu Journal of invertebrate pathology 117, 61-67, 2014 | 51 | 2014 |