| Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9 HL Li, N Fujimoto, N Sasakawa, S Shirai, T Ohkame, T Sakuma, ... Stem cell reports 4 (1), 143-154, 2015 | 663 | 2015 |
| Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9 S Nakade, T Tsubota, Y Sakane, S Kume, N Sakamoto, M Obara, ... Nature communications 5 (1), 5560, 2014 | 550 | 2014 |
| Robust in vitro induction of human germ cell fate from pluripotent stem cells K Sasaki, S Yokobayashi, T Nakamura, I Okamoto, Y Yabuta, K Kurimoto, ... Cell stem cell 17 (2), 178-194, 2015 | 510 | 2015 |
| MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems T Sakuma, S Nakade, Y Sakane, KIT Suzuki, T Yamamoto Nature protocols 11 (1), 118-133, 2016 | 439 | 2016 |
| Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system T Sakuma, A Nishikawa, S Kume, K Chayama, T Yamamoto Scientific reports 4 (1), 5400, 2014 | 430 | 2014 |
| Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice T Aida, K Chiyo, T Usami, H Ishikubo, R Imahashi, Y Wada, KF Tanaka, ... Genome biology 16, 1-11, 2015 | 309 | 2015 |
| Sterol side chain reductase 2 is a key enzyme in the biosynthesis of cholesterol, the common precursor of toxic steroidal glycoalkaloids in potato S Sawai, K Ohyama, S Yasumoto, H Seki, T Sakuma, T Yamamoto, ... The Plant Cell 26 (9), 3763-3774, 2014 | 284 | 2014 |
| Precise in-frame integration of exogenous DNA mediated by CRISPR/Cas9 system in zebrafish Y Hisano, T Sakuma, S Nakade, R Ohga, S Ota, H Okamoto, T Yamamoto, ... Scientific reports 5 (1), 8841, 2015 | 274 | 2015 |
| Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity T Sakuma, H Ochiai, T Kaneko, T Mashimo, D Tokumasu, Y Sakane, ... Scientific reports 3 (1), 3379, 2013 | 256 | 2013 |
| Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases T Watanabe, H Ochiai, T Sakuma, HW Horch, N Hamaguchi, T Nakamura, ... Nature communications 3 (1), 1017, 2012 | 248 | 2012 |
| Efficient TALEN construction and evaluation methods for human cell and animal applications T Sakuma, S Hosoi, K Woltjen, K Suzuki, K Kashiwagi, H Wada, H Ochiai, ... Genes to Cells 18 (4), 315-326, 2013 | 244 | 2013 |
| Human induced pluripotent stem cell–derived podocytes mature into vascularized glomeruli upon experimental transplantation S Sharmin, A Taguchi, Y Kaku, Y Yoshimura, T Ohmori, T Sakuma, ... Journal of the American Society of Nephrology 27 (6), 1778-1791, 2016 | 231 | 2016 |
| Simple knockout by electroporation of engineered endonucleases into intact rat embryos T Kaneko, T Sakuma, T Yamamoto, T Mashimo Scientific reports 4 (1), 6382, 2014 | 220 | 2014 |
| EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step S Ninagawa, T Okada, Y Sumitomo, Y Kamiya, K Kato, S Horimoto, ... Journal of Cell Biology 206 (3), 347-356, 2014 | 174 | 2014 |
| The microtubule-depolymerizing activity of a mitotic kinesin protein KIF2A drives primary cilia disassembly coupled with cell proliferation T Miyamoto, K Hosoba, H Ochiai, E Royba, H Izumi, T Sakuma, ... Cell reports 10 (5), 664-673, 2015 | 172 | 2015 |
| Generation of a nonhuman primate model of severe combined immunodeficiency using highly efficient genome editing K Sato, R Oiwa, W Kumita, R Henry, T Sakuma, R Ito, R Nozu, T Inoue, ... Cell stem cell 19 (1), 127-138, 2016 | 163 | 2016 |
| Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases S Ansai, T Sakuma, T Yamamoto, H Ariga, N Uemura, R Takahashi, ... Genetics 193 (3), 739-749, 2013 | 142 | 2013 |
| Organoids from nephrotic disease-derived iPSCs identify impaired NEPHRIN localization and slit diaphragm formation in kidney podocytes S Tanigawa, M Islam, S Sharmin, H Naganuma, Y Yoshimura, F Haque, ... Stem cell reports 11 (3), 727-740, 2018 | 140 | 2018 |
| Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes C Shukunami, A Takimoto, Y Nishizaki, Y Yoshimoto, S Tanaka, S Miura, ... Scientific reports 8 (1), 3155, 2018 | 136 | 2018 |
| Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells H Ochiai, T Sugawara, T Sakuma, T Yamamoto Scientific reports 4 (1), 7125, 2014 | 121 | 2014 |
Takashi YamamotoHiroshima UniversityVerified email at hiroshima-u.ac.jp
