フォロー
George Lountos
George Lountos
Basic Science Program, Frederick National Laboratory for Cancer Research
確認したメール アドレス: mail.nih.gov
タイトル
引用先
引用先
Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity
D Needle, GT Lountos, DS Waugh
Acta Crystallographica Section D: Biological Crystallography 71 (5), 1102-1111, 2015
1202015
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1 …
AG Jobson, GT Lountos, PL Lorenzi, J Llamas, J Connelly, D Cerna, ...
Journal of Pharmacology and Experimental Therapeutics 331 (3), 816-826, 2009
1122009
The Crystal Structure of NAD(P)H Oxidase from Lactobacillus sanfranciscensis:  Insights into the Conversion of O2 into Two Water Molecules by the Flavoenzyme,
GT Lountos, R Jiang, WB Wellborn, TL Thaler, AS Bommarius, AM Orville
Biochemistry 45 (32), 9648-9659, 2006
1112006
Role of Glu312 in Binding and Positioning of the Substrate for the Hydride Transfer Reaction in Choline Oxidase,
O Quaye, GT Lountos, Fan, AM Orville, G Gadda
Biochemistry 47 (1), 243-256, 2008
1052008
Crystallographic, Spectroscopic, and Computational Analysis of a Flavin C4a−Oxygen Adduct in Choline Oxidase,
AM Orville, GT Lountos, S Finnegan, G Gadda, R Prabhakar
Biochemistry 48 (4), 720-728, 2009
722009
Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion
GT Lountos, BP Austin, S Nallamsetty, DS Waugh
Protein Science 18 (2), 467-474, 2009
572009
Utilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia pestis Outer Protein H (YopH …
M Bahta, GT Lountos, B Dyas, SE Kim, RG Ulrich, DS Waugh, TR Burke Jr
Journal of medicinal chemistry 54 (8), 2933-2943, 2011
522011
Engineering of glycerol dehydrogenase for improved activity towards 1, 3-butanediol
H Zhang, GT Lountos, CB Ching, R Jiang
Applied microbiology and biotechnology 88, 117-124, 2010
392010
Insights into the allosteric inhibition of the SUMO E2 enzyme Ubc9
WM Hewitt, GT Lountos, K Zlotkowski, SD Dahlhauser, LB Saunders, ...
Angewandte Chemie 128 (19), 5797-5801, 2016
342016
Structure of B-DNA with Cations Tethered in the Major Groove,
T Moulaei, T Maehigashi, GT Lountos, S Komeda, D Watkins, MP Stone, ...
Biochemistry 44 (20), 7458-7468, 2005
332005
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor
GT Lountos, JE Tropea, D Zhang, AG Jobson, Y Pommier, RH Shoemaker, ...
Protein science 18 (1), 92-100, 2009
302009
Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic …
GT Lountos, XZ Zhao, E Kiselev, JE Tropea, D Needle, Y Pommier, ...
Nucleic Acids Research 47 (19), 10134-10150, 2019
282019
Overproduction, purification and structure determination of human dual-specificity phosphatase 14
GT Lountos, JE Tropea, S Cherry, DS Waugh
Acta Crystallographica Section D: Biological Crystallography 65 (10), 1013-1020, 2009
242009
Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy
GT Lountos, AG Jobson, JE Tropea, CR Self, G Zhang, Y Pommier, ...
Journal of structural biology 176 (3), 292-301, 2011
232011
A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH
F Liu, RM Hakami, B Dyas, M Bahta, GT Lountos, DS Waugh, RG Ulrich, ...
Bioorganic & medicinal chemistry letters 20 (9), 2813-2816, 2010
232010
Crystal Structures and Functional Studies of T4moD, the Toluene 4-Monooxygenase Catalytic Effector Protein,
GT Lountos, KH Mitchell, JM Studts, BG Fox, AM Orville
Biochemistry 44 (19), 7131-7142, 2005
232005
Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery
I Botos, GT Lountos, W Wu, S Cherry, R Ghirlando, AM Kudzhaev, ...
Current Research in Structural Biology 1, 13-20, 2019
212019
A small-molecule microarray approach for the identification of E2 enzyme inhibitors in ubiquitin-like conjugation pathways
K Zlotkowski, WM Hewitt, RS Sinniah, JE Tropea, D Needle, GT Lountos, ...
SLAS DISCOVERY: Advancing Life Sciences R&D 22 (6), 760-766, 2017
202017
Phosphotyrosine substrate sequence motifs for dual specificity phosphatases
BM Zhao, SL Keasey, JE Tropea, GT Lountos, BK Dyas, S Cherry, ...
Plos one 10 (8), e0134984, 2015
202015
Structure of human dual-specificity phosphatase 27 at 2.38 Å resolution
GT Lountos, JE Tropea, DS Waugh
Acta Crystallographica Section D: Biological Crystallography 67 (5), 471-479, 2011
202011
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論文 1–20