| A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma H Hatakeyama, H Akita, H Harashima Advanced drug delivery reviews 63 (3), 152-160, 2011 | 673 | 2011 |
| Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid H Hatakeyama, H Akita, K Kogure, M Oishi, Y Nagasaki, Y Kihira, M Ueno, ... Gene therapy 14 (1), 68-77, 2007 | 488 | 2007 |
| The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors H Hatakeyama, H Akita, H Harashima Biological and pharmaceutical bulletin 36 (6), 892-899, 2013 | 474 | 2013 |
| A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo Y Sato, H Hatakeyama, Y Sakurai, M Hyodo, H Akita, H Harashima Journal of controlled release 163 (3), 267-276, 2012 | 327 | 2012 |
| A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo H Hatakeyama, E Ito, H Akita, M Oishi, Y Nagasaki, S Futaki, H Harashima Journal of Controlled Release 139 (2), 127-132, 2009 | 297 | 2009 |
| Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid H Hatakeyama, H Akita, E Ito, Y Hayashi, M Oishi, Y Nagasaki, R Danev, ... Biomaterials 32 (18), 4306-4316, 2011 | 232 | 2011 |
| Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery G Kibria, H Hatakeyama, N Ohga, K Hida, H Harashima Journal of controlled release 153 (2), 141-148, 2011 | 226 | 2011 |
| Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes H Hatakeyama, H Akita, E Ishida, K Hashimoto, H Kobayashi, T Aoki, ... International journal of pharmaceutics 342 (1-2), 194-200, 2007 | 225 | 2007 |
| Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo H Hatakeyama, H Akita, K Maruyama, T Suhara, H Harashima International journal of pharmaceutics 281 (1-2), 25-33, 2004 | 203 | 2004 |
| Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system G Kibria, H Hatakeyama, H Harashima Archives of pharmacal research 37, 4-15, 2014 | 193 | 2014 |
| Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA Y Sakurai, H Hatakeyama, Y Sato, H Akita, K Takayama, S Kobayashi, ... Biomaterials 32 (24), 5733-5742, 2011 | 139 | 2011 |
| A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer SY Wu, R Rupaimoole, F Shen, S Pradeep, CV Pecot, C Ivan, ... Nature communications 7 (1), 11169, 2016 | 135 | 2016 |
| Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system Y Sakurai, H Hatakeyama, Y Sato, M Hyodo, H Akita, H Harashima Molecular Therapy 21 (6), 1195-1203, 2013 | 129 | 2013 |
| 2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity SY Wu, X Yang, KM Gharpure, H Hatakeyama, M Egli, MH McGuire, ... Nature communications 5 (1), 3459, 2014 | 128 | 2014 |
| RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system Y Sakurai, H Hatakeyama, Y Sato, M Hyodo, H Akita, N Ohga, K Hida, ... Journal of controlled release 173, 110-118, 2014 | 125 | 2014 |
| Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy K Takara, H Hatakeyama, G Kibria, N Ohga, K Hida, H Harashima Journal of Controlled Release 162 (1), 225-232, 2012 | 120 | 2012 |
| Lipid envelope-type nanoparticle incorporating a multifunctional peptide for systemic siRNA delivery to the pulmonary endothelium K Kusumoto, H Akita, T Ishitsuka, Y Matsumoto, T Nomoto, R Furukawa, ... ACS nano 7 (9), 7534-7541, 2013 | 108 | 2013 |
| A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells S Warashina, T Nakamura, Y Sato, Y Fujiwara, M Hyodo, H Hatakeyama, ... Journal of controlled release 225, 183-191, 2016 | 107 | 2016 |
| The effect of liposomal size on the targeted delivery of doxorubicin to Integrin αvβ3-expressing tumor endothelial cells G Kibria, H Hatakeyama, N Ohga, K Hida, H Harashima Biomaterials 34 (22), 5617-5627, 2013 | 103 | 2013 |
| A multifunctional envelope-type nanodevice for use in nanomedicine: concept and applications T Nakamura, H Akita, Y Yamada, H Hatakeyama, H Harashima Accounts of chemical research 45 (7), 1113-1121, 2012 | 99 | 2012 |
Kyoko HidaHokkaido UniversityVerified email at den.hokudai.ac.jp
