| The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability FH Niesen, H Berglund, M Vedadi Nature protocols 2 (9), 2212-2221, 2007 | 2857 | 2007 |
| Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty Jr, ... Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006 | 736 | 2006 |
| Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation P Rellos, ACW Pike, FH Niesen, E Salah, WH Lee, F Von Delft, S Knapp PLoS biology 8 (7), e1000426, 2010 | 287 | 2010 |
| The import receptor for the peroxisomal targeting signal 2 (PTS2) in Saccharomyces cerevisiae is encoded by the PAS7 gene. P Rehling, M Marzioch, F Niesen, E Wittke, M Veenhuis, WH Kunau The EMBO Journal 15 (12), 2901-2913, 1996 | 237 | 1996 |
| Kinase inhibitor selectivity profiling using differential scanning fluorimetry O Fedorov, FH Niesen, S Knapp Kinase Inhibitors: Methods and Protocols, 109-118, 2012 | 183 | 2012 |
| Activation segment dimerization: a mechanism for kinase autophosphorylation of non‐consensus sites ACW Pike, P Rellos, FH Niesen, A Turnbull, AW Oliver, SA Parker, ... The EMBO journal 27 (4), 704-714, 2008 | 181 | 2008 |
| DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer GB Deutsch, EM Zielonka, D Coutandin, TA Weber, B Schäfer, ... Cell 144 (4), 566-576, 2011 | 162 | 2011 |
| Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation AN Bullock, S Das, JE Debreczeni, P Rellos, O Fedorov, FH Niesen, ... Structure 17 (3), 352-362, 2009 | 133 | 2009 |
| The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins O Gileadi, S Knapp, WH Lee, BD Marsden, S Müller, FH Niesen, ... Journal of structural and functional genomics 8, 107-119, 2007 | 79 | 2007 |
| A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation B Lucic, Y Zhang, O King, R Mendoza-Maldonado, M Berti, FH Niesen, ... Nucleic acids research 39 (5), 1703-1717, 2011 | 77 | 2011 |
| Conformational stability and activity of p73 require a second helix in the tetramerization domain D Coutandin, F Löhr, FH Niesen, T Ikeya, TA Weber, B Schäfer, ... Cell Death & Differentiation 16 (12), 1582-1589, 2009 | 77 | 2009 |
| Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization AP Turnbull, D Kümmel, B Prinz, C Holz, J Schultchen, C Lang, ... The EMBO Journal 24 (5), 875-884, 2005 | 70 | 2005 |
| Structural basis for substrate specificity in human monomeric carbonyl reductases ES Pilka, FH Niesen, WH Lee, Y El-Hawari, JE Dunford, G Kochan, ... PLoS One 4 (10), e7113, 2009 | 68 | 2009 |
| Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder DS Froese, S Healy, M McDonald, G Kochan, U Oppermann, FH Niesen, ... Molecular genetics and metabolism 100 (1), 29-36, 2010 | 62 | 2010 |
| An automated in vitro protein folding screen applied to a human dynactin subunit C Scheich, FH Niesen, R Seckler, K Büssow Protein Science 13 (2), 370-380, 2004 | 61 | 2004 |
| High-Affinity Inhibitors of Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships FH Niesen, L Schultz, A Jadhav, C Bhatia, K Guo, DJ Maloney, ES Pilka, ... PLoS One 5 (11), e13719, 2010 | 45 | 2010 |
| Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone TJ Zimmermann, FH Niesen, ES Pilka, S Knapp, U Oppermann, ME Maier Bioorganic & medicinal chemistry 17 (2), 530-536, 2009 | 37 | 2009 |
| X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880 BA Manjasetty, FH Niesen, H Delbrück, F Götz, V Sievert, K Büssow, ... Walter de Gruyter 385 (10), 935-942, 2004 | 31 | 2004 |
| X‐ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma BA Manjasetty, C Quedenau, V Sievert, K Büssow, F Niesen, H Delbrück, ... Proteins: Structure, Function, and Bioinformatics 55 (1), 214-217, 2004 | 30 | 2004 |
| An approach to quality management in structural biology: Biophysical selection of proteins for successful crystallization FH Niesen, A Koch, U Lenski, U Harttig, Y Roske, U Heinemann, ... Journal of structural biology 162 (3), 451-459, 2008 | 28 | 2008 |
