Gene body methylation can alter gene expression and is a therapeutic target in cancer X Yang, H Han, DD De Carvalho, FD Lay, PA Jones, G Liang Cancer cell 26 (4), 577-590, 2014 | 1136 | 2014 |
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells J Tan, X Yang, L Zhuang, X Jiang, W Chen, PL Lee, RKM Karuturi, ... Genes & development 21 (9), 1050-1063, 2007 | 1029 | 2007 |
Targeting DNA methylation for epigenetic therapy X Yang, F Lay, H Han, PA Jones Trends in pharmacological sciences 31 (11), 536-546, 2010 | 382 | 2010 |
DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival DD De Carvalho, S Sharma, JS You, SF Su, PC Taberlay, TK Kelly, ... Cancer Cell 21 (5), 655-667, 2012 | 327 | 2012 |
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb–E2F1 activity through a feedback loop by targeting CDK6 and CDC25A X Yang, M Feng, X Jiang, Z Wu, Z Li, M Aau, Q Yu Genes & development 23 (20), 2388-2393, 2009 | 282 | 2009 |
DACT3 is an epigenetic regulator of Wnt/β-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications X Jiang, J Tan, J Li, S Kivimäe, X Yang, L Zhuang, PL Lee, MTW Chan, ... Cancer cell 13 (6), 529-541, 2008 | 279 | 2008 |
DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter H Han, CC Cortez, X Yang, PW Nichols, PA Jones, G Liang Human molecular genetics 20 (22), 4299-4310, 2011 | 249 | 2011 |
Loss of epigenetic information as a cause of mammalian aging JH Yang, M Hayano, PT Griffin, JA Amorim, MS Bonkowski, ... Cell 186 (2), 305-326. e27, 2023 | 245 | 2023 |
CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells X Yang, RKM Karuturi, F Sun, M Aau, K Yu, R Shao, LD Miller, PBO Tan, ... PloS one 4 (4), e5011, 2009 | 199 | 2009 |
DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells CE Duymich, J Charlet, X Yang, PA Jones, G Liang Nature communications 7 (1), 11453, 2016 | 131 | 2016 |
Allelic methylation levels of the non-coding VTRNA2-1 located on chromosome 5q31. 1 predict outcome in AML. MB Treppendahl, X Qiu, A Søgaard, X Yang, C Nandrup-Bus, C Hother, ... Blood, 2011 | 117 | 2011 |
Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation M Feng, Z Li, M Aau, CH Wong, X Yang, Q Yu Oncogene 30 (19), 2242-2251, 2011 | 100 | 2011 |
Functional DNA demethylation is accompanied by chromatin accessibility K Pandiyan, JS You, X Yang, C Dai, XJ Zhou, SB Baylin, PA Jones, ... Nucleic Acids Research, 2013 | 95 | 2013 |
Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells F Sun, E Chan, Z Wu, X Yang, VE Marquez, Q Yu Molecular cancer therapeutics 8 (12), 3191-3202, 2009 | 92 | 2009 |
Gene Reactivation by 5-Aza-2′-Deoxycytidine–Induced Demethylation Requires SRCAP–Mediated H2A. Z Insertion to Establish Nucleosome Depleted Regions X Yang, H Noushmehr, H Han, C Andreu-Vieyra, G Liang, PA Jones PLoS Genetics 8 (3), e1002604, 2012 | 81 | 2012 |
Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress J Li, J Tan, L Zhuang, B Banerjee, X Yang, JFL Chau, PL Lee, MP Hande, ... Cancer Research 67 (23), 11317-11326, 2007 | 75 | 2007 |
A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium W Sun, T Triche Jr, J Malvar, P Gaynon, R Sposto, X Yang, H Bittencourt, ... Blood, The Journal of the American Society of Hematology 131 (10), 1145-1148, 2018 | 64 | 2018 |
Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells H Han, X Yang, K Pandiyan, G Liang PLoS One 8 (9), e75136, 2013 | 54 | 2013 |
Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer’s disease E Coninx, YC Chew, X Yang, W Guo, A Coolkens, S Baatout, L Moons, ... Aging (Albany NY) 12 (20), 20817, 2020 | 26 | 2020 |
Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer J Tan, X Yang, X Jiang, J Zhou, Z Li, PL Lee, B Li, P Robson, Q Yu Cell death & disease 5 (7), e1324-e1324, 2014 | 20 | 2014 |